Effect of Xenotransplantation of Cell Cultures Enriched with Stem and Progenitor Cells on Hormonal Profile of Rats with Abdominal Cryptorchism
| Autor: | A A Kamalov, Galina Pavlova, V. I. Kirpatovskii, E A Efremov, E. V. Orlova, E. Yu. Plotnikov, Gennady T. Sukhikh, D A Okhobotov, E. I. Zaraiskii, R. A. Poltavtseva |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Xenotransplantation medicine.medical_treatment Transplantation Heterologous Cell- and Tissue-Based Therapy Biology General Biochemistry Genetics and Molecular Biology Internal medicine Cryptorchidism medicine Animals Testosterone Progenitor cell Cells Cultured Stem Cells General Medicine Luteinizing Hormone Hyperplasia medicine.disease Rats Endocrinology Cell culture Human fetal Follicle Stimulating Hormone Stem cell Hormone |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 146:517-521 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-009-0325-5 |
| Popis: | We present the results of application of cell cultures enriched with stem and progenitor cells for the treatment of experimental abdominal cryptorchism in outbred albino rats. Xenotransplantation of human fetal enriched cell cultures was performed to animals with experimental cryptorchism during orchiolysis. Total testosterone, luteinizing and follicle-stimulating hormones were assayed by immunochemiluminescent method. It was found that xenotransplantation of cell cultures enriched with stem and progenitor cells normalized the level of total testosterone, decreased the concentrations of gonadotropic hormones, reduced hyperplasia of Leydig cells and the number of chromaffin granules, and restored normochromism of Leydig cells nuclei. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink