Pyrazole-Thiazole Core-Containing Analogs Exhibit Adjunctive Activity with Meropenem against Carbapenem-Resistant Enterobacteriaceae (CRE)
| Autor: | Kenneth P. Smith, James E. Kirby, Roman Manetsch, Mintesinot Kassu, Chungsik Kim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
Antibiotics Carbapenem-resistant enterobacteriaceae Microbial Sensitivity Tests Pyrazole 01 natural sciences Biochemistry Meropenem chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine General Pharmacology Toxicology and Pharmaceutics Solubility Thiazole Pharmacology Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry Combinatorial chemistry 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry Thiazoles Carbapenem-Resistant Enterobacteriaceae Molecular Medicine Pyrazoles Efflux Antibacterial activity medicine.drug |
| Zdroj: | ChemMedChem. 16(18) |
| ISSN: | 1860-7187 |
| Popis: | Pyrazole-thiazole core-containing compound KP-40 and 20 novel derivatives were designed and synthesized through traditional SAR analysis. These molecules displayed adjunctive activity with meropenem against Gram-negative bacteria evidenced by a range of fractional inhibitory concentration (FIC=0.5-0.25) and minimum adjunctive concentration (MAC=128-32 μM) values. Of this series of molecules, four compounds displayed notable adjunctive potential, with FIC and MAC values of 0.25 and 32 μM, respectively. Moreover, the solubility of these compounds was improved to an acceptable range. Further analysis using our "in house" permeation and efflux multi parameter optimization (PEMPO) algorithm revealed key physicochemical properties that may be critical for the development of active Gram-negative antibacterials. Taking PEMPO scores into consideration prior to executing synthesis of analogs may be a simple, yet rapid and effective strategy that can be used in conjunction with traditional SAR approaches to aid in the design of potent Gram-negative antibacterials. |
| Databáze: | OpenAIRE |
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