Local anaesthetic transperineal (LATP) prostate biopsy using a probe‐mounted transperineal access system: a multicentre prospective outcome analysis
| Autor: | Rick Popert, Tom Leslie, Richard J. Bryant, Tom Austin, J. Francisco Lopez, Freddie C. Hamdy, Catherine Lovegrove, Charlotte Foley, Utsav D. Reddy, Nithesh Ranasinha, Raj Persad, Thomas Reeves, Luke Stroman, Ben Eddy, Stefanos Bolomytis, C. Richard Bell, Dominic Hodgson, Simon Brewster, Yiannis Philippou, Alastair D. Lamb, Aaron Leiblich, Mohammed Elsaghir, Angus Campbell, Jasper Bondad, Altan Omer, Curtis Phelan, Simon van Rij, Wayne Lam |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Prostate biopsy Biopsy Urology medicine.medical_treatment 030232 urology & nephrology Perineum 03 medical and health sciences 0302 clinical medicine medicine Humans General anaesthesia Prospective Studies Prospective cohort study Aged medicine.diagnostic_test Urinary retention business.industry Transperineal biopsy Prostate Middle Aged Tolerability 030220 oncology & carcinogenesis Nerve block Feasibility Studies Radiology medicine.symptom business Anesthesia Local |
| Zdroj: | BJU International. 128:311-318 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/bju.15337 |
| Popis: | OBJECTIVES To assess the feasibility of local anaesthetic transperineal (LATP) technique using a single-freehand transperineal (TP) access device, and report initial prostate cancer (PCa) detection, infection rates, and tolerability. PATIENTS AND METHODS Observational study of a multicentre prospective cohort, including all consecutive cases. LATP was performed in three settings: (i) first biopsy in suspected PCa, (ii) confirmatory biopsies for active surveillance, and (iii) repeat biopsy in suspected PCa. All patients received pre-procedure antibiotics according to local hospital guidelines. Local anaesthesia was achieved by perineal skin infiltration and periprostatic nerve block without sedation. Ginsburg protocol principles were followed for systematic biopsies including cognitive magnetic resonance imaging-targeted biopsies when needed using the PrecisionPoint™ TP access device. Procedure-related complications and oncological outcomes were prospectively and consecutively collected. A validated questionnaire was used in a subset of centres to collect data on patient-reported outcome measures (PROMs). RESULTS Some 1218 patients underwent LATP biopsies at 10 centres: 55%, 24%, and 21% for each of the three settings, respectively. Any grade PCa was diagnosed in 816 patients (67%), of which 634 (52% of total) had clinically significant disease. Two cases of sepsis were documented (0.16%) and urinary retention was observed in 19 patients (1.6%). PROMs were distributed to 419 patients, with a 56% response rate (n = 234). In these men, pain during the biopsy was described as either 'not at all' or 'a little' painful by 64% of patients. Haematuria was the most common reported symptom (77%). When exploring attitude to re-biopsy, 48% said it would be 'not a problem' and in contrast 8.1% would consider it a 'major problem'. Most of the patients (81%) described the biopsy as a 'minor or moderate procedure tolerable under local anaesthesia', while 5.6% perceived it as a 'major procedure that requires general anaesthesia'. CONCLUSION Our data suggest that LATP biopsy using a TP access system mounted to the ultrasound probe achieves excellent PCa detection, with a very low sepsis rate, and is safe and well tolerated. We believe a randomised controlled trial comparing LATP with transrectal ultrasound-guided biopsy (TRUS) to investigate the relative trade-offs between each biopsy technique would be helpful. |
| Databáze: | OpenAIRE |
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