Monitoring of Lung Motion in Patients With Malignant Pleural Mesothelioma Using Two-Dimensional and Three-Dimensional Dynamic Magnetic Resonance Imaging
| Autor: | Christian Fink, Sebastian Ley, Michael Klopp, Felix J.F. Herth, Hans-Ulrich Kauczor, Michael Puderbach, Christian Thieke, Marc-André Weber, Siegfried Tuengerthal, Claus D. Claussen, Alexandra Sandner, Hans-Peter Meinzer, Max Schoebinger, Christian Plathow |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Mesothelioma Spirometry medicine.medical_specialty Movement Pleural Neoplasms Vital Capacity Antineoplastic Agents Imaging Three-Dimensional medicine Humans Radiology Nuclear Medicine and imaging In patient Lung Aged medicine.diagnostic_test Pleural mesothelioma business.industry Magnetic resonance imaging General Medicine Middle Aged respiratory system Magnetic Resonance Imaging respiratory tract diseases medicine.anatomical_structure Dynamic contrast-enhanced MRI Female Therapy monitoring Radiology Lung Volume Measurements business |
| Zdroj: | Investigative Radiology. 41:443-448 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/01.rli.0000208222.03256.ba |
| Popis: | To monitor lung motion in patients with malignant pleural mesothelioma (MPM) before and after chemotherapy (CHT) using 2-dimensional (2D) and 3-dimensional (3D) dynamic MRI (dMRI) in comparison with spirometry.Twenty-two patients with MPM were examined before CHT, as well as after 3 and 6 CHT cycles (3 months and 6 months) using 2D dMRI (trueFISP; 3 images/s) and 3D dMRI (FLASH 3D, 1 slab (52 slices)/s) using parallel imaging in combination with view-sharing technique. Maximum craniocaudal lung dimensions (2D) and lung volumes (3D) were monitored, separated into the tumor-bearing and nontumor-bearing hemithorax. Vital capacity (VC) was measured for comparison using spirometry.Using 2D technique, there was a significant difference between the tumor-bearing and the nontumor-bearing hemithorax before CHT (P0.01) and after 3 CHT cycles (P0.05), whereas difference was not significant in the second control. In the tumor-bearing hemithorax, mobility increased significantly from the status before versus after 3 CHT cycles (4.1 +/- 1.1 cm vs. 4.8 +/- 1.4 cm, P0.05). Using 3D technique, at maximum inspiration, the volume of the tumor-bearing hemithorax was 0.6 +/- 0.4 L and of the nontumor-bearing hemithorax 1.25 +/- 0.4 L before CHT. In the follow-up exams, these volumes changed to 1.05 +/- 0.4 L (P0.05) and 1.4 +/- 0.5 L, respectively. Using spirometry, there was no significant change in VC (1.9 +/- 0.4 L vs. 2.2 +/- 0.7 L vs. 2.2 +/- 0.9 L).dMRI is capable of monitoring changes in lung motion and volumetry in patients with MPM not detected by global spirometry. Thus, dMRI is proposed for use as a further measure of therapy response. |
| Databáze: | OpenAIRE |
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