Bioanalytical methods for the determination of synthetic cannabinoids and metabolites in biological specimens
| Autor: | Abdulaziz A. Aldlgan, Hazel J. Torrance |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
RCS-8
Bioanalysis Chromatography integumentary system Stereochemistry 010401 analytical chemistry JWH-019 JWH-307 RCS-4 01 natural sciences 0104 chemical sciences Analytical Chemistry AB-CHMINACA 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry nervous system JWH-398 Synthetic cannabinoids medicine 030216 legal & forensic medicine tissues Spectroscopy medicine.drug |
| ISSN: | 0165-9936 |
| Popis: | Recently the use of synthetic cannabinoids (SCs) has increased around the world. As a result, the importance for accurate analysis of SCs in human biological matrices is evident and continues to be especially challenging due to their chemical structures being constantly modified. Many methods have been published recently for the analysis of SCs in human biological samples. This review provides an overview of the analytical methods used for the analysis of SCs and their metabolites in biological specimens with a special focus on chromatographic analysis and sample preparation. Liquid chromatography assay is the most commonly used for confirmation purposes of SCs and their metabolites in biological matrices. In blood and oral fluid, analysis of SCs must be very sensitive. In urine, SCs have extensive metabolism pathways; therefore the main target compounds are their hydroxyl and carboxyl metabolites, which is important to recognise when establishing clinical and forensic toxicology analytical methods. |
| Databáze: | OpenAIRE |
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