Synthesis of Imidazo[1,2-a]pyridines as Antiviral Agents
| Autor: | Mavel S, De Clercq E, Chavignon O, Graciela Andrei, Lhassani M, Alain Gueiffier, Robert Snoeck, Chapat Jp, Myriam Witvrouw, Teulade Jc, Elhakmaoui A, Jan Balzarini |
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| Rok vydání: | 1998 |
| Předmět: |
Herpesvirus 3
Human Imidazopyridine Pyridines Stereochemistry viruses Drug Evaluation Preclinical Cytomegalovirus Antiviral Agents Chemical synthesis Virus Cell Line Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Therapeutic index Thioether Chlorocebus aethiops Drug Discovery Side chain Animals Humans Structure–activity relationship Vero Cells Bicyclic molecule Imidazoles virus diseases chemistry Molecular Medicine HeLa Cells |
| Zdroj: | Journal of Medicinal Chemistry. 41:5108-5112 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm981051y |
| Popis: | The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed. |
| Databáze: | OpenAIRE |
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