ABCB1 and ABCG2 expression in the placenta and fetus: an interspecies comparison
| Autor: | Maria Kummu, Päivi Myllynen, E. Sieppi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
ATP Binding Cassette Transporter Subfamily B Abcg2 Placenta Guinea Pigs Gene Expression ATP-binding cassette transporter Toxicology Bioinformatics Mice Fetus Species Specificity Pregnancy Internal medicine Gene expression medicine Toxicokinetics ATP Binding Cassette Transporter Subfamily G Member 2 Animals Humans ATP Binding Cassette Transporter Subfamily B Member 1 reproductive and urinary physiology Pharmacology Kidney biology General Medicine medicine.disease Neoplasm Proteins Rats medicine.anatomical_structure Endocrinology Pharmaceutical Preparations embryonic structures biology.protein ATP-Binding Cassette Transporters Female sense organs Rabbits |
| Zdroj: | Expert opinion on drug metabolismtoxicology. 6(11) |
| ISSN: | 1744-7607 |
| Popis: | ABCB1 and ABCG2 are efflux transporters which have a major impact on the pharmacological behavior of numerous drugs. They are expressed, for example, in the intestine, liver, kidney, BBB and placenta. It has become evident that ABCB1 and ABCG2 modify the pharmaco/toxicokinetics in the placenta and fetus and may consequently affect the outcome of pregnancy.Comprehensive literature searches were done using PubMed (until June 2010) to identify publications on ABCB1 and ABCG2 expression in placenta and fetal tissues in human, mouse, rat, guinea-pig and rabbit.In this review, we aim to provide an overview of the current knowledge on the ABCB1 and ABCG2 transporter expression profiles in the placenta and fetal tissues in humans relative to other species.The available information on ABCB1 and ABCG2 temporal expression profiles in placenta and fetus indicates rather good correlation among human, mouse and rat although some specific differences have been reported. However, at this point no detailed comparisons or comparative functional data are available. Detailed knowledge on the expression patterns and functional activity of ABCB1 and ABCG2 transporters placenta and developing embryo/fetus in different species could possibly help the interspecies extrapolation. |
| Databáze: | OpenAIRE |
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