Roles of Nuclear Receptors in Vascular Calcification

Autor: Giulia Chinetti, Jaap G Neels
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Vascular smooth muscle
QH301-705.5
Cellular differentiation
extracellular matrix
Receptors
Cytoplasmic and Nuclear
Inflammation
Review
030204 cardiovascular system & hematology
vascular cells
arterial wall
Catalysis
Inorganic Chemistry
Extracellular matrix
03 medical and health sciences
0302 clinical medicine
Calcification
Physiologic
transcription factors
medicine
Animals
Humans
mineralization
Physical and Theoretical Chemistry
Biology (General)
Vascular Calcification
Molecular Biology
Transcription factor
QD1-999
Spectroscopy
Regulation of gene expression
calcium
Chemistry
Organic Chemistry
General Medicine
medicine.disease
Computer Science Applications
Cell biology
030104 developmental biology
Nuclear receptor
Gene Expression Regulation
Disease Susceptibility
medicine.symptom
gene regulation
Biomarkers
Calcification
Protein Binding
Signal Transduction
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 6491, p 6491 (2021)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Vascular calcification is defined as an inappropriate accumulation of calcium depots occurring in soft tissues, including the vascular wall. Growing evidence suggests that vascular calcification is an actively regulated process, sharing similar mechanisms with bone formation, implicating both inhibitory and inducible factors, mediated by osteoclast-like and osteoblast-like cells, respectively. This process, which occurs in nearly all the arterial beds and in both the medial and intimal layers, mainly involves vascular smooth muscle cells. In the vascular wall, calcification can have different clinical consequences, depending on the pattern, localization and nature of calcium deposition. Nuclear receptors are transcription factors widely expressed, activated by specific ligands that control the expression of target genes involved in a multitude of pathophysiological processes, including metabolism, cancer, inflammation and cell differentiation. Some of them act as drug targets. In this review we describe and discuss the role of different nuclear receptors in the control of vascular calcification.
Databáze: OpenAIRE
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