Histological findings in foetuses congenitally infected by cytomegalovirus
| Autor: | Giorgio Gardini, Federica Baccolini, Maria Paola Landini, Maria Pia Foschini, Tiziana Lazzarotto, Angela Chiereghin, Donatella Santini, Giulia Piccirilli, Stefania Lega, Maria Paola Bonasoni, Marcello Lanari, Liliana Gabrielli, Brunella Guerra, Evangelia Petrisli |
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| Přispěvatelé: | Gabrielli L., Bonasoni M.P., Lazzarotto T., Lega S., Santini D., Foschini M.P., Guerra B., Baccolini F., Piccirilli G., Chiereghin A., Petrisli E., Gardini G., Lanari M., Landini M.P. |
| Rok vydání: | 2009 |
| Předmět: |
Human cytomegalovirus
medicine.medical_specialty Pathology CYTOMEGALOVIRUS Placenta FOETAL DAMAGE Congenital cytomegalovirus infection Brain damage Biology Central nervous system disease Fetus Pregnancy Virology medicine Humans CONGENITAL INFECTION reproductive and urinary physiology Lung food and beverages virus diseases Brain Viral Load Amniotic Fluid medicine.disease Infectious Diseases medicine.anatomical_structure embryonic structures Cytomegalovirus Infections Female Histopathology Sensorineural hearing loss medicine.symptom |
| Zdroj: | Journal of Clinical Virology. 46:S16-S21 |
| ISSN: | 1386-6532 |
| DOI: | 10.1016/j.jcv.2009.09.026 |
| Popis: | Background Congenital cytomegalovirus (CMV) infection is a major cause of central nervous system damage leading to sensorineural hearing loss, mental retardation and cerebral palsy. Objectives Identify the type of organ involvement and understand the histopathogenesis of damage in foetuses of women with a CMV-highly positive amniotic fluid. Study design 34 foetuses with congenital CMV infection documented by prenatal diagnosis were studied. Three foetuses died in utero . The remaining pregnancies were electively terminated at 20–21 weeks gestation. Results Foetal organs positive for CMV antigens were: placenta (100%), pancreas (100%), lung (87%), kidney (87%), liver (71%), brain (55%) and heart (44%). Inflammatory infiltrate was almost always present in CMV-infected foetal organs and the severity of the inflammatory response was correlated with the organ damage. Brain damage with necrosis was observed in 33% (9/27) and a mild telencephalic leukoencephalopathy in 22% (6/27) of foetuses studied. Conclusions Focal necrosis was observed very frequently in organs such as pancreases, livers, hearts and kidneys. However the damage in these organs is likely to be resolved by parenchymal regeneration. Brain damage, which seems to be the results of a combined effect of viral infection, inflammatory infiltration and hypoxia due to severe placentitis, is less likely to be resolved because of the low regeneration ability of this organ. |
| Databáze: | OpenAIRE |
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