Long-term treatment with ramipril favourably modifies the haemostatic response to acute submaximal exercise in hypertensives
| Autor: | Dimitrios Th. Kremastinos, Theodoros Theodoridis, Vasiliki Christopoulou-Cokkinou, Helen Triantafyllidi, Matina Koutroumbi, Maria Anastasiou-Nana, John Lekakis, Vassiliki Galea |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Platelets
Male Ramipril Medicine (General) medicine.medical_specialty Time Factors medicine.medical_treatment Blood Pressure Essential hypertension R5-920 Endocrinology Von Willebrand factor Internal medicine Fibrinolysis Internal Medicine medicine Humans Aerobic exercise Platelet Endothelial dysfunction Exercise Demography Fibrin Hemostasis biology business.industry Antithrombin Thrombin Middle Aged medicine.disease Hypertension biology.protein Endothelium Vascular business medicine.drug |
| Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 14 (2013) |
| ISSN: | 1752-8976 1470-3203 |
| Popis: | Introduction: Hypertension links to a prothrombotic state driven by endothelial dysfunction, reduced fibrinolytic potential and platelet hyperactivity. We hypothesized that ramipril treatment would favourably modify the haemostatic response to a submaximal aerobic exercise session in hypertensives. Methods: Twenty-four hypertensive patients underwent a submaximal exercise test before and after 13±2 months of treatment with ramipril ± hydrochlorothiazide. Hypercoagulability (prothrombin fragments [PF1+2], thrombin– antithrombin complex [TAT] and D-dimers [Dd]), fibrinolytic activity (plasmin–a2-antiplasmin complex [PAP]), endothelial function (von Willebrand factor [vWf] and soluble thrombomodulin [sTM]), and platelet function (soluble P-selectin [sPsel]) were measured before, at peak and one hour after exercise. Results: Antihypertensive treatment resulted in an increase of PAP, vWf and sTM. During the first exercise, PF1+2 were mildly increased at peak exercise ( p |
| Databáze: | OpenAIRE |
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