Thyroid function parameters during a selenium repetition/depletion study in phenylketonuric subjects
| Autor: | N Vanovervelt, B François, M Van Caillie-Bertrand, J B Vanderpas, D. Vanden Berghe, André Herchuelz, C. van Hoorebeke, M. Calomme |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Male
Thyroid Hormones congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Adolescent Thyroid Gland chemistry.chemical_element Type I 5'-deiodinase Iodide Peroxidase Selenium Cellular and Molecular Neuroscience Phenylketonurias Internal medicine medicine Humans Child Molecular Biology Pharmacology chemistry.chemical_classification Glutathione Peroxidase Glutathione peroxidase nutritional and metabolic diseases Cell Biology Endocrinology chemistry Thyroid hormones Molecular Medicine Female Thyroid function |
| Zdroj: | Experientia |
| Popis: | Phenylketonuric (PKU) subjects have a limited supply of selenium (Se) in their phenylalanine-restricted diet. A Se repletion (1 microgram Se/kg/day)/depletion study was conducted in PKU children to determine the effect of Se on thyroid function parameters. The initial plasma Se concentration (mean +/- SD: 0.26 +/- 0.12 mumol/L, p0.00003, n = 10) and glutathione peroxidase (GSH-Px) activity (140 +/- 58 U/L, p0.00003, n = 10) were significantly lower compared to age-matched controls. After 14 weeks of supplementation, the plasma Se concentration (mean +/- SD: 0.74 +/- 0.20 mumol/L) normalized (normal range: 0.57-1.15 mumol/L, mean +/- SD: 0.76 +/- 0.13 mumol/L, n = 32) and remained stable thereafter during repletion. Plasma GSH-Px activity reached normal values after 18 weeks of supplementation (312 +/- 57 U/L; normal range: 238-492 U/L, mean +/- SD: 345 +/- 54 U/L, n = 32) and increased significantly for up to eight weeks thereafter (332 +/- 52 U/L). Individual and mean thyroid parameters were initially normal in all cases. The mean concentrations of plasma thyroxine (T4: p0.025), free T4 (FT4: p0.01) and reverse triiodothyronine (rT3: p0.005) decreased to 75% of their initial value within three weeks of Se supplementation and remained stable thereafter, within a normal physiological range during selenium supplementation. They increased back to their initial values three weeks (T4: p0.05, FT4: p0.05) and six weeks (rT3: p0.025) respectively, after the end of the supplementation. In conclusion, Se supplementation modifies thyroid function parameters in Se-deficient PKU subjects most likely by an increase in activity of type I 5'-deiodinase (5'-DIase I). |
| Databáze: | OpenAIRE |
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