Association Between Systemic Lupus Erythematosus and Myasthenia Gravis: Coincidence or Sequelae?
| Autor: | Bilal Haider Malik, Sumit Raut, Ayesha Masood, Ishani Reddy, Faryal Mustansir Sahi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Neuromuscular disease
Anti-nuclear antibody autoimmune neuromuscular disease medicine.medical_treatment Population acetylcholine receptor antibody 030204 cardiovascular system & hematology Allergy/Immunology 03 medical and health sciences 0302 clinical medicine Rheumatology anti-nuclear antibody Internal Medicine medicine anti dsdna antibody education thymectomy Autoimmune disease myasthenia gravis education.field_of_study business.industry sle General Engineering Autoantibody neuromuscular disease medicine.disease Myasthenia gravis Review article Thymectomy Immunology business 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.8422 |
| Popis: | Systemic lupus erythematosus (SLE) is a systemic autoimmune disease and myasthenia gravis (MG) is an organ-specific autoimmune disease, both may exhibit positive anti-nuclear antibodies and a female preponderance. They may have similar features and can coexist in a patient or precede one another. This review article is based on electronic searches using PubMed as the primary database. Most of the articles used for this review were published in the last ten years with the exception of seven articles which were from 1995-2009. No guidelines have been followed. A total of 55 research articles were found related to the topic of this review article, and further scanning was done to eliminate some articles that did not meet the criteria. The coexistence of autoimmune diseases has been reported in many cases. The prevalence of a second autoimmune disease is higher among patients with a primary diagnosis of autoimmune disease than the general population. The prevalence of SLE in MG patients or vice-versa is greater than the general population. The association has been hypothesized to many mechanisms: thymectomy resulting in loss of central tolerance and generation of autoantibodies, regulatory T cell dysfunction, the dysregulated function of Fas receptor (CD95), anti-malarial drugs directly affecting the neuromuscular junction, the role of chemokine CXCL13 and GM-CSF in the pathogenesis. The association is rare, and the presence of one should be closely followed for further progression into other diseases. More research work needs to be done for a clear conclusion. |
| Databáze: | OpenAIRE |
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