Retrospective analysis of clinical and pathomorphological features of lupus nephritis in children
| Autor: | Irena Wikiera-Magott, Beata Bieniaś, Małgorzata Pańczyk-Tomaszewska, Beata Banaszak, Małgorzata Barabasz, Anna Wieczorkiewicz-Płaza, Hanna Szymanik-Grzelak, Magdalena Drożyńska-Duklas, Marcin Tkaczyk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Adolescent Lupus nephritis Kidney Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Retrospective analysis Humans Pediatric nephrology 030212 general & internal medicine Retrospective Studies Proteinuria business.industry Medical record Clinical course General Medicine Prognosis medicine.disease Lupus Nephritis 030220 oncology & carcinogenesis Female Poland medicine.symptom business Nephrotic range proteinuria Follow-Up Studies Glomerular Filtration Rate |
| Zdroj: | Advances in Medical Sciences. 66:128-137 |
| ISSN: | 1896-1126 |
| Popis: | The aim of the study was to evaluate the clinical course and pathomorphological correlations in Polish children with the diagnosis of lupus nephritis (LN).We retrospectively analyzed the medical records of 39 children hospitalized due to LN in 7 pediatric nephrology units in Poland between 2010 and 2019. Demographic data, clinical symptoms at the onset of LN and laboratory parameters were reviewed. We analyzed Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), histological LN findings with the activity (IA) and chronicity index (IC).We examined 32 girls and 7 boys, median age at LN onset was 14.75 (IQR 13.0-16.0) years, SLEDAI of 22.0 (IQR 18.0-27.0) points; LN histological class: IV (59.4%), III (18.9%), III/V (10.8%), IV/V (8.1%), VI (2.7%); IA 8.0 (IQR 6.0-11.0) points, IC 1.05 (IQR 0-2.0) points. Children with nephrotic (n = 22) and non-nephrotic (n = 17) proteinuria differed in median Hb level (9.55, IQR 8.3-11.2 vs 10.9, IQR 10.1-11.6 g/L; P 0.05), albumin level (2.5, IQR 2.1-3.19 vs 3.6, IQR 3.4-4.1 g/dL; P 0.001), proteinuria (5.76, IQR 3.0-7.5 vs 1.08, IQR 0.53-1.50 g/day; P 0.0001), eGFR (53.9, IQR 27.0-68.8 vs 96.7, IQR 73.8-106.2 mL/min/1.73 mProliferative forms of LN in children may have a varying clinical presentation. Children with LN with nephrotic range proteinuria have lower Hb level, lower eGFR and higher occurrence of hypertension. Hb level is the significant predictor of eGFR90 mL/min/1.73 m |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect