Generation of 2′,3′-Cyclic Phosphate-Containing RNAs as a Hidden Layer of the Transcriptome
| Autor: | Megumi Shigematsu, Takuya Kawamura, Yohei Kirino |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:QH426-470 Review Computational biology angiogenin (ANG) 2′ Transcriptome 03 medical and health sciences chemistry.chemical_compound 3′-cyclic phosphate (cP) non-coding RNA (ncRNA) cP-containing RNA (cP-RNA) Genetics Ribonuclease Genetics (clinical) chemistry.chemical_classification tRNA half 030102 biochemistry & molecular biology biology Chemistry RNA Phosphate lcsh:Genetics 030104 developmental biology Enzyme biology.protein Molecular Medicine Hidden layer RNA Cleavage ribonuclease cP-RNA-seq Biogenesis |
| Zdroj: | Frontiers in Genetics, Vol 9 (2018) Frontiers in Genetics |
| ISSN: | 1664-8021 |
| DOI: | 10.3389/fgene.2018.00562 |
| Popis: | Cellular RNA molecules contain phosphate or hydroxyl ends. A 2′,3′-cyclic phosphate (cP) is one of the 3′-terminal forms of RNAs mainly generated from RNA cleavage by ribonucleases. Although transcriptome profiling using RNA-seq has become a ubiquitous tool in biological and medical research, cP-containing RNAs (cP-RNAs) form a hidden transcriptome layer, which is infrequently recognized and characterized, because standard RNA-seq is unable to capture them. Despite cP-RNAs’ invisibility in RNA-seq data, increasing evidence indicates that they are not accumulated simply as non-functional degradation products; rather, they have physiological roles in various biological processes, designating them as noteworthy functional molecules. This review summarizes our current knowledge of cP-RNA biogenesis pathways and their catalytic enzymatic activities, discusses how the cP-RNA generation affects biological processes, and explores future directions to further investigate cP-RNA biology. |
| Databáze: | OpenAIRE |
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