Late radiation damage in prostate cancer patients treated by high dose external radiotherapy in relation to rectal dose
| Autor: | W.G.J.M. Smit, J.J. Seldenrath, Arendjan Wijnmaalen, W. L. J. Van Putten, P.A. Helle, B. Van Der Werf-Messing |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Radiation proctitis medicine.medical_treatment Rectum Prostate cancer Prostate Risk Factors medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Proctitis Radiation Injuries Aged Retrospective Studies Aged 80 and over Radiation Epithelioma business.industry Incidence Prostatic Neoplasms Dose-Response Relationship Radiation Radiotherapy Dosage Middle Aged medicine.disease Radiation therapy medicine.anatomical_structure Oncology Radiology business Nuclear medicine Tomography X-Ray Computed |
| Zdroj: | International journal of radiation oncology, biology, physics. 18(1) |
| ISSN: | 0360-3016 |
| Popis: | A retrospective analysis of the incidence of radiation proctitis was performed in 154 patients with carcinoma of the prostate treated with external radiotherapy assisted by CT-scan planning from 1983 to 1985. An attempt was made to assess a dose-response relationship for proctitis. Multivariate Cox regression analysis showed that previous bowel disease or surgery, anterior rectal dose, and average rectal dose contributed to a higher risk of proctitis. The anterior rectal dose was the most important indicator. No statistically significant correlation was found for the posterior rectal dose. The actuarial 2-year incidence of moderate or severe proctitis was 22% for anterior rectal doses less than 70 Gy and 20% for anterior rectal doses between 70 and 75 Gy, but increased to 60% when the dose was more than 75 Gy. A dose effect relation was evident, with a sharp dose-response gradient around 75 Gy at the anterior rectal wall. |
| Databáze: | OpenAIRE |
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