Association between season of vaccination and antibody levels against infectious diseases
| Autor: | G. A. M. Berbers, Liesbeth Mollema, T. C. Abreu, H. Korthals Altes, Hendriek C. Boshuizen |
|---|---|
| Přispěvatelé: | Epidemiology and Data Science |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Adolescent Epidemiology serology Meningococcal Vaccines Measles Rubella Antibodies 03 medical and health sciences Young Adult 0302 clinical medicine Immunity Seroepidemiologic Studies vaccine Medicine Humans Hepatitis B Vaccines 030212 general & internal medicine Vaccines Combined Seroconversion Child Diphtheria-Tetanus-Pertussis Vaccine Immunization Schedule Haemophilus Vaccines Netherlands Original Paper Vaccines Conjugate business.industry Tetanus seasonality Diphtheria Vaccination Infant medicine.disease Poliomyelitis Poliovirus Vaccine Inactivated 030104 developmental biology Infectious Diseases Cross-Sectional Studies Child Preschool Immunology Childhood vaccination schedule Communicable Disease Control Female Seasons business Measles-Mumps-Rubella Vaccine |
| Zdroj: | Epidemiology and Infection Abreu, T C, Boshuizen, H, Mollema, L, Berbers, G A M & Korthals Altes, H 2020, ' Association between season of vaccination and antibody levels against infectious diseases ', Epidemiology and Infection, pp. 1-29 . https://doi.org/10.1017/S0950268820002691 Epidemiology and Infection, 1-29. Cambridge University Press STARTPAGE=1;ENDPAGE=29;ISSN=0950-2688;TITLE=Epidemiology and Infection |
| ISSN: | 1469-4409 0950-2688 |
| Popis: | Vaccination has reduced the disease burden of vaccine-preventable diseases. However, the extent to which seasonal cycles of immunity could influence vaccine-induced immunity is not well understood. A national cross-sectional serosurveillance study performed in the Netherlands (Pienter-2) yielded data to investigate whether season of vaccination was associated with antibody responses induced by DT-IPV (diphtheria, tetanus and poliomyelitis), MMR (measles, mumps and rubella) and meningococcus C (MenC) vaccines in children. In total, 434 children met the inclusion criteria to study DT-IPV immunity, 811 for MMR and 311 for MenC. Differences in log(antibody levels) by season of vaccination were investigated with linear multivariable regression analyses. Seroconversion rates varied according to season of vaccination for rubella (90% of autumn-vaccinated childrenvs.99% of winter-vaccinated had concentrations above cut-off levels). Summer-vaccinated boys showed a slower decline of tetanus antibodies (6% per month), in comparison with winter-vaccinated boys. In conclusion, season of vaccination showed little association with immunological protection. However, a number of associations were seen with aP-value of about 0.03; and adding data from a just-completed nationwide serological study might add more power to the current study. Further immunological and longitudinal investigations could help understand the mechanisms of seasonal influence in vaccine-induced responses. |
| Databáze: | OpenAIRE |
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