Photopheresis in the red man or pre-Sézary syndrome
| Autor: | U. Brodthagen, P. Bjerring, Helmer Søgaard, Zachariae H |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Erythroderma Dermatology Photopheresis hemic and lymphatic diseases Extracorporeal photochemotherapy Medicine Humans Sezary Syndrome Mechlorethamine Treatment Failure Red Man Syndrome Aged Chemotherapy business.industry Leukapheresis Middle Aged medicine.disease Peripheral T-cell lymphoma Acitretin Lymphoma Prednisone business Precancerous Conditions Dermatitis Exfoliative Follow-Up Studies |
| Zdroj: | Dermatology (Basel, Switzerland). 190(2) |
| ISSN: | 1018-8665 |
| Popis: | The beneficial effect of extracorporeal photochemotherapy has clearly been established for patients with cutaneous T-cell lymphoma with Sézary's syndrome. But this treatment has not been used in the red man syndrome or pre-Sézary syndrome. Some of these patients do not respond sufficiently or do not tolerate other therapies.The purpose of this open study was to evaluate the clinical efficacy of photopheresis in this group of patients.Seven patients with the red man syndrome were treated on 2 consecutive days every 4 weeks for 6-22 months. Six had been on systemic steroids and 3 had also received retinoids without sufficient effects. All were initially treated with topical nitrogen mustard but no longer tolerated this treatment.All signs of erythroderma disappeared in 6 of the 7 patients. All systemic therapy could be discontinued in all but 2 patients. No side effects were observed.Photopheresis may be an effective alternative treatment for this group of patients, when other types of therapy have failed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|