VR1-, VRL-1- and P2X3 receptor-immunoreactive innervation of the rat temporomandibular joint
| Autor: | Tomohiro Fukunaga, Tomosada Sugimoto, Masako Fujita, H.W. Jin, Teruko Takano-Yamamoto, Hiroyuki Ichikawa |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Stilbamidines Calcitonin Gene-Related Peptide Receptors Drug TRPV Cation Channels Cell Count Calcitonin gene-related peptide Ion Channels Rats Sprague-Dawley Trigeminal ganglion Nerve Fibers stomatognathic system Internal medicine medicine Animals Receptor Molecular Biology Cell Size Fluorescent Dyes Temporomandibular Joint Receptors Purinergic P2 Chemistry General Neuroscience Immunohistochemistry Retrograde tracing Rats Temporomandibular joint body regions stomatognathic diseases medicine.anatomical_structure Endocrinology nervous system Calcitonin Nociceptor Neurology (clinical) Synovial membrane Receptors Purinergic P2X3 Developmental Biology |
| Zdroj: | Brain Research. 1008:131-136 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2004.02.029 |
| Popis: | Immunohistochemistry for vanilloid receptor subtype 1 (VR1), vanilloid receptor 1-like receptor (VRL-1) and P2X3 receptor was performed in the rat temporomandibular joint (TMJ). Blood vessels in the articular disk and capsule, the synovial membrane and the fibrous tissue around the condylar process were innervated by VR1- or P2X3 receptor-immunoreactive (ir) nerve fibers. However, VRL-1-immunoreactivity (ir) could not be detected in the TMJ. Retrograde tracing and immunohistochemical methods revealed that 25%, 41% and 52% of TMJ neurons in the trigeminal ganglion (TG) exhibited VR1-, VRL-1- and P2X3 receptor-ir, respectively. VR1-ir TMJ neurons were mostly small to medium-sized, whereas VRL-1- and P2X3 receptor-ir TMJ neurons were predominantly medium-sized to large. In addition, 73%, 28% and 44% of VR1-, VRL-1- and P2X3 receptor-ir TMJ neurons, respectively, coexpressed calcitonin gene-related peptide (CGRP)-ir. The present study suggests that the TMJ has abundant nociceptors which respond to vanilloid compounds, protons, heat and extracellular ATP. |
| Databáze: | OpenAIRE |
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