Plasma sex hormone binding globulin concentration and binding capacity in children before and during puberty
| Autor: | David C. Townend, Roland Hähnel, Linda E. Lawder, Ian R. Lee, John D. Wetherall |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.medical_specialty Immunodiffusion Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Steroid Endocrinology Sex hormone-binding globulin Sex Factors Prepuberty Internal medicine Sex Hormone-Binding Globulin Blood plasma medicine Humans Child Binding protein Puberty Age Factors Dihydrotestosterone General Medicine Metabolism Child Preschool biology.protein Female Sex Hormone Binding Protein |
| Zdroj: | Acta endocrinologica. 109(2) |
| ISSN: | 0001-5598 |
| Popis: | The steroid binding capacity and concentration of plasma sex hormone binding globulin have been compared in 116 children aged between 2 and 14 years. Concentration was measured by electroimmunodiffusion standardised with reference to the mass of the pure protein and binding capacity by quantitating the binding of radiolabelled 5α-dihydrotestosterone. Binding capacity correlated highly with concentration in all subjects and neither differed significantly between the sexes before or during puberty. However, both were significantly lower in pubertal than in pre-pubertal children. These findings suggest the metabolism of the protein is similar in boys and girls and that the fall in its steroid binding capacity at puberty in fact is due to a fall in its concentration rather than to changes in its physicochemical properties. |
| Databáze: | OpenAIRE |
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