Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
| Autor: | Ana C. Calpena, Josefa Badia, Maria Luisa García, Camila Folle, Natalia Díaz-Garrido, Ana Marqués, Elena Sánchez-López, Marta Espina, Laura Baldomà |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
Skin delivery system medicine.medical_treatment Antibiotics Pharmaceutical Science Medicine (miscellaneous) Pharmacology medicine.disease_cause Applied Microbiology and Biotechnology Antioxidants chemistry.chemical_compound Polylactic Acid-Polyglycolic Acid Copolymer Acne Vulgaris Thymol Acne Skin Nanopartícules Antimicrobial Anti-Bacterial Agents Drug delivery systems Skin diseases Sistemes d'alliberament de medicaments medicine.anatomical_structure Molecular Medicine Biotechnology medicine.drug_class Biomedical Engineering Bioengineering Microbial Sensitivity Tests Skin microbiota Cell Line medicine Medical technology Humans Particle Size R855-855.5 Epidermis (botany) Research Propionibacteriaceae Hair follicle medicine.disease Malalties de la pell chemistry PLGA nanoparticles Nanoparticles Cutibacterium acnes Staphylococcus TP248.13-248.65 |
| Zdroj: | Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-21 (2021) Journal of Nanobiotechnology Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 1477-3155 |
| Popis: | Background Acne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason, we developed polymeric nanoparticles encapsulating thymol, a natural active compound with antimicrobial and antioxidant properties. In this work, optimization physicochemical characterization, biopharmaceutical behavior and therapeutic efficacy of this novel nanostructured system were assessed. Results Thymol NPs (TH-NP) resulted on suitable average particle size below 200 nm with a surface charge around − 28 mV and high encapsulation efficiency (80%). TH-NP released TH in a sustained manner and provide a slow-rate penetration into the hair follicle, being highly retained inside the skin. TH-NP possess a potent antimicrobial activity against Cutibacterium acnes and minor effect towards Staphylococcus epidermis, the major resident of the healthy skin microbiota. Additionally, the stability and sterility of developed NPs were maintained along storage. Conclusion TH-NP showed a promising and efficient alternative for the treatment of skin acne infection, avoiding antibiotic administration, reducing side effects, and preventing microbial drug resistance, without altering the healthy skin microbiota. Additionally, TH-NP enhanced TH antioxidant activity, constituting a natural, preservative-free, approach for acne treatment. Graphical Abstract |
| Databáze: | OpenAIRE |
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