Synthesis of glucuronides of multidrug resistance reversing drug MS-209
| Autor: | Nobuyuki Fukazawa, Kazunori Mabuchi, Tsuneji Suzuki |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Drug
Stereochemistry medicine.drug_class Glucuronate Metabolite media_common.quotation_subject Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents Glucuronates Carboxamide Urine Biochemistry Chemical synthesis chemistry.chemical_compound Drug Discovery medicine Humans Molecular Biology media_common Organic Chemistry Drug Resistance Multiple Multiple drug resistance chemistry Drug Resistance Neoplasm Quinolines Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:659-662 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(99)00056-6 |
| Popis: | We synthesized the glucuronides of MS-209 to identify the two main unknown metabolites in human urine. Reaction of MS-209 and glucuronyl trichloroacetimidate gave two β-isomers, which were each glucuronate of ( R )- and ( S )-MS-209. These spectrum data were identical with the metabolites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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