Circulation and characterization of seasonal influenza viruses in Cambodia, 2012‐2015

Autor: Savuth Chin, Yi-Mo Deng, Phalla Y, Sareth Rith, Srey Viseth Horm, Erik A. Karlsson, Amy Parry, Philippe Dussart, Chau Darapheak, Naomi Komadina, Sovann Ly, Ian G. Barr, Seng Heng, David Saunders, Reiko Tsuyouka, Philippe Buchy, Vanra Ieng, Aeron C. Hurt, Paul F. Horwood, Borann Sar, Kim Lay Chea, Lon Chanthap
Přispěvatelé: Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), James Cook University (JCU), Ministry of Health [Phnom Penh], National Institute of Public Health [Phnom Penh, Cambodge], Armed Forces Research Institute of Medical Sciences [Bangkok] (AFRIMS), Centers for Disease Control and Prevention [Phnom Penh], Embassy of the United States of America, World Health Organization [Phnom Penh] (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, Monash University [Melbourne], GlaxoSmithKline Vaccines [Singapore], GlaxoSmithKline [Headquarters, London, UK] (GSK), The study was funded by the World Health Organization office in Cambodia.
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Epidemiology
medicine.disease_cause
[SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics
Phylogenetics and taxonomy
Seasonal influenza
MESH: Influenza Vaccines
chemistry.chemical_compound
0302 clinical medicine
MESH: Child
Influenza A virus
Child
MESH: Influenza B virus
MESH: Aged
0303 health sciences
MESH: Middle Aged
MESH: Drug Resistance
Viral
MESH: Influenza
Human
MESH: Infant
Newborn
virus diseases
Middle Aged
influenza B virus
MESH: Infant
3. Good health
Infectious Diseases
A(H1N1)pdm09
Influenza Vaccines
MESH: Young Adult
Child
Preschool
030220 oncology & carcinogenesis
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
surveillance
MESH: Sentinel Surveillance
Original Article
Female
Seasons
Cambodia
A(H3N2)
MESH: Whole Genome Sequencing
medicine.drug
Adult
Pulmonary and Respiratory Medicine
MESH: Antiviral Agents
Oseltamivir
Adolescent
MESH: Influenza A virus
Biology
Antiviral Agents
Virus
Young Adult
03 medical and health sciences
Zanamivir
Drug Resistance
Viral
Influenza
Human
medicine
Humans
influenza A virus
Respiratory samples
Aged
030304 developmental biology
MESH: Adolescent
MESH: Humans
Whole Genome Sequencing
MESH: Cambodia
MESH: Child
Preschool
Infant
Newborn
Public Health
Environmental and Occupational Health
Antiviral resistance
Infant
Influenza a
MESH: Adult
Original Articles
Virology
MESH: Male
chemistry
Sentinel Surveillance
MESH: Seasons
MESH: Female
Zdroj: Influenza and Other Respiratory Viruses
Influenza and Other Respiratory Viruses, Wiley Open Access, 2019, 13 (5), pp.465-476. ⟨10.1111/irv.12647⟩
ISSN: 1750-2640
1750-2659
Popis: International audience; Background: Influenza virus circulation is monitored through the Cambodian in- fluenza-like illness (ILI) sentinel surveillance system and isolates are characterized by the National Influenza Centre (NIC). Seasonal influenza circulation has previ- ously been characterized by year-round activity and a peak during the rainy season (June-November).Objectives: We documented the circulation of seasonal influenza in Cambodia for 2012-2015 and investigated genetic, antigenic, and antiviral resistance characteris- tics of influenza isolates.Patients/Methods: Respiratory samples were collected from patients presenting with influenza-like illness (ILI) at 11 hospitals throughout Cambodia. First-line screen- ing was conducted by the National Institute of Public Health and the Armed Forces Research Institute of Medical Sciences. Confirmation of testing and genetic, anti- genic and antiviral resistance characterization was conducted by Institute Pasteur in Cambodia, the NIC. Additional virus characterization was conducted by the WHO Collaborating Centre for Reference and Research on Influenza (Melbourne, Australia).Results: Between 2012 and 2015, 1,238 influenza-positive samples were submitted to the NIC. Influenza A(H3N2) (55.3%) was the dominant subtype, followed by in- fluenza B (30.9%; predominantly B/Yamagata-lineage) and A(H1N1)pdm09 (13.9%). Circulation of influenza viruses began earlier in 2014 and 2015 than previously de- scribed, coincident with the emergence of A(H3N2) clades 3C.2a and 3C.3a, respec- tively. There was high diversity in the antigenicity of A(H3N2) viruses, and to a smaller extent influenza B viruses, during this period, with some mismatches with the north- ern and southern hemisphere vaccine formulations. All isolates tested were suscepti- ble to the influenza antiviral drugs oseltamivir and zanamivir.Conclusions: Seasonal and year-round co-circulation of multiple influenza types/sub- types were detected in Cambodia during 2012-2015.
Databáze: OpenAIRE
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