Circulation and characterization of seasonal influenza viruses in Cambodia, 2012‐2015
Autor: | Savuth Chin, Yi-Mo Deng, Phalla Y, Sareth Rith, Srey Viseth Horm, Erik A. Karlsson, Amy Parry, Philippe Dussart, Chau Darapheak, Naomi Komadina, Sovann Ly, Ian G. Barr, Seng Heng, David Saunders, Reiko Tsuyouka, Philippe Buchy, Vanra Ieng, Aeron C. Hurt, Paul F. Horwood, Borann Sar, Kim Lay Chea, Lon Chanthap |
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Přispěvatelé: | Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), James Cook University (JCU), Ministry of Health [Phnom Penh], National Institute of Public Health [Phnom Penh, Cambodge], Armed Forces Research Institute of Medical Sciences [Bangkok] (AFRIMS), Centers for Disease Control and Prevention [Phnom Penh], Embassy of the United States of America, World Health Organization [Phnom Penh] (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, Monash University [Melbourne], GlaxoSmithKline Vaccines [Singapore], GlaxoSmithKline [Headquarters, London, UK] (GSK), The study was funded by the World Health Organization office in Cambodia. |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Epidemiology medicine.disease_cause [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics Phylogenetics and taxonomy Seasonal influenza MESH: Influenza Vaccines chemistry.chemical_compound 0302 clinical medicine MESH: Child Influenza A virus Child MESH: Influenza B virus MESH: Aged 0303 health sciences MESH: Middle Aged MESH: Drug Resistance Viral MESH: Influenza Human MESH: Infant Newborn virus diseases Middle Aged influenza B virus MESH: Infant 3. Good health Infectious Diseases A(H1N1)pdm09 Influenza Vaccines MESH: Young Adult Child Preschool 030220 oncology & carcinogenesis [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology surveillance MESH: Sentinel Surveillance Original Article Female Seasons Cambodia A(H3N2) MESH: Whole Genome Sequencing medicine.drug Adult Pulmonary and Respiratory Medicine MESH: Antiviral Agents Oseltamivir Adolescent MESH: Influenza A virus Biology Antiviral Agents Virus Young Adult 03 medical and health sciences Zanamivir Drug Resistance Viral Influenza Human medicine Humans influenza A virus Respiratory samples Aged 030304 developmental biology MESH: Adolescent MESH: Humans Whole Genome Sequencing MESH: Cambodia MESH: Child Preschool Infant Newborn Public Health Environmental and Occupational Health Antiviral resistance Infant Influenza a MESH: Adult Original Articles Virology MESH: Male chemistry Sentinel Surveillance MESH: Seasons MESH: Female |
Zdroj: | Influenza and Other Respiratory Viruses Influenza and Other Respiratory Viruses, Wiley Open Access, 2019, 13 (5), pp.465-476. ⟨10.1111/irv.12647⟩ |
ISSN: | 1750-2640 1750-2659 |
Popis: | International audience; Background: Influenza virus circulation is monitored through the Cambodian in- fluenza-like illness (ILI) sentinel surveillance system and isolates are characterized by the National Influenza Centre (NIC). Seasonal influenza circulation has previ- ously been characterized by year-round activity and a peak during the rainy season (June-November).Objectives: We documented the circulation of seasonal influenza in Cambodia for 2012-2015 and investigated genetic, antigenic, and antiviral resistance characteris- tics of influenza isolates.Patients/Methods: Respiratory samples were collected from patients presenting with influenza-like illness (ILI) at 11 hospitals throughout Cambodia. First-line screen- ing was conducted by the National Institute of Public Health and the Armed Forces Research Institute of Medical Sciences. Confirmation of testing and genetic, anti- genic and antiviral resistance characterization was conducted by Institute Pasteur in Cambodia, the NIC. Additional virus characterization was conducted by the WHO Collaborating Centre for Reference and Research on Influenza (Melbourne, Australia).Results: Between 2012 and 2015, 1,238 influenza-positive samples were submitted to the NIC. Influenza A(H3N2) (55.3%) was the dominant subtype, followed by in- fluenza B (30.9%; predominantly B/Yamagata-lineage) and A(H1N1)pdm09 (13.9%). Circulation of influenza viruses began earlier in 2014 and 2015 than previously de- scribed, coincident with the emergence of A(H3N2) clades 3C.2a and 3C.3a, respec- tively. There was high diversity in the antigenicity of A(H3N2) viruses, and to a smaller extent influenza B viruses, during this period, with some mismatches with the north- ern and southern hemisphere vaccine formulations. All isolates tested were suscepti- ble to the influenza antiviral drugs oseltamivir and zanamivir.Conclusions: Seasonal and year-round co-circulation of multiple influenza types/sub- types were detected in Cambodia during 2012-2015. |
Databáze: | OpenAIRE |
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