Effect of melatonin on the behaviour of rats with continuous light-induced hypertension
| Autor: | Martina Mullerova, Stefan Zorad, Július Hodosy, Fedor Simko, Tomas Baka, Kristina Repova, Peter Celec, Ludovit Paulis, Peter Slavkovsky, Kristina Krajcirovicova, Michaela Adamcova, Silvia Aziriova |
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| Rok vydání: | 2018 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Light Physiology Biophysics Blood Pressure 030204 cardiovascular system & hematology Continuous light Melatonin 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Rats Wistar Behavior Animal business.industry fungi General Medicine Increased systolic blood pressure Rats Endocrinology Hypertension business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | General physiology and biophysics. 37:469-473 |
| ISSN: | 1338-4325 |
| DOI: | 10.4149/gpb_2017061 |
| Popis: | This study investigated whether continuous light exposure (CLE) results in behavioural disturbances in rats and whether melatonin can modify these potential changes. Four groups of 3-month-old Wistar rats were treated as follows for six weeks: control, melatonin, CLE, and CLE with melatonin. CLE increased systolic blood pressure and melatonin reduced it. No changes in behavioural patterns by CLE were observed. In the controls, melatonin reduced both exploration and locomotion but these parameters remained uninfluenced in the CLE. We conclude that melatonin exerted a different impact on behaviour in controls and in the CLE group. |
| Databáze: | OpenAIRE |
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