Bronchial brush biopsies for studies of epithelial inflammation in stable asthma and nonobstructive chronic bronchitis
| Autor: | M Soderberg, Staffan Ahlstedt, Bengt Andersson, Olle Löwhagen, Gerdt C. Riise, Sven Larsson, I Enander |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Chronic bronchitis Pathology medicine.medical_specialty Biopsy Tryptase Sensitivity and Specificity Epithelium Reference Values Administration Inhalation medicine Humans Bronchitis Eosinophil cationic protein medicine.diagnostic_test biology business.industry Epithelial Cells Bronchial Brush Biopsy respiratory system Eosinophil Middle Aged Asthma respiratory tract diseases Bronchoalveolar lavage medicine.anatomical_structure Chronic Disease biology.protein Methacholine Female Steroids business Bronchoalveolar Lavage Fluid Biomarkers medicine.drug |
| Zdroj: | The European respiratory journal. 9(8) |
| ISSN: | 0903-1936 |
| Popis: | Recently, bronchial brush biopsy (BBB) has been introduced as a complimentary method to bronchial forceps biopsy for the study of bronchial epithelial cells. We wanted to determine whether epithelial inflammatory cells in bronchial brush biopsies can reflect mucosal inflammation assessed indirectly by levels of cellular activation markers in bronchial lavage fluid. We studied 15 healthy controls, 11 asthmatics with regular steroid inhalation therapy, 13 asthmatics without steroids, and 10 smokers with nonobstructive chronic bronchitis. Differential counts of epithelial and inflammatory cells were made from the BBB material. Bronchial lavage levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), tryptase, hyaluronan and interleukin-8 (IL-8) were measured as indirect markers for inflammatory cell activation. We found an increased percentage of eosinophil granulocytes in the BBB from the steroid-untreated asthmatic patients (1.16%) in comparison to the other groups (0.11%, 0.09% and 0.02%, respectively; p |
| Databáze: | OpenAIRE |
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