Uremic Tumoral Calcinosis: Preliminary Observations Suggesting an Association With Aberrant Vitamin D Homeostasis
| Autor: | Michael J. Econs, Gayle Murphy, L. Darryl Quarles, Salutario Martinez, Bruce Lobaugh, Kenneth W. Lyles |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Calcitriol End stage renal disease Hyperphosphatemia Renal Dialysis Calcinosis Internal medicine polycyclic compounds medicine Vitamin D and neurology Homeostasis Humans Vitamin D Retrospective Studies Uremia Hyperparathyroidism business.industry Middle Aged medicine.disease Radiography Endocrinology Nephrology Tumoral calcinosis lipids (amino acids peptides and proteins) business medicine.drug Calcification |
| Zdroj: | American Journal of Kidney Diseases. 18:706-710 |
| ISSN: | 0272-6386 |
| DOI: | 10.1016/s0272-6386(12)80614-7 |
| Popis: | Periarticular tumoral calcification is a unique form of soft tissue calcification that occurs infrequently in patients with end-stage renal disease. The mechanism underlying such massive periarticular calcifications is unknown. The radiographic similarity between uremic tumoral calcifications and those found in hereditary tumoral calcinosis, a disorder of calcitriol and phosphorus homeostasis, caused us to examine whether abnormalities in vitamin D metabolism were associated with uremic calcinosis as well. We examined two uremic subjects with massive periarticular tumoral calcifications and found that they had inappropriately high serum calcitriol levels for the degree of renal function, hyperparathyroidism, and hyperphosphatemia. The source of calcitriol could not be identified in one subject, but likely was derived from granulomatous tissue in the other. In the subject with marrow granulomas, we found that calcitonin administration further stimulated calcitriol production. Although epidemiological studies are needed to confirm this preliminary association between calcitriol and uremic tumoral calcinosis, our observations suggest that normal serum calcitriol levels in association with hyperphosphatemia may be a contributing factor in the development of this rare disorder. |
| Databáze: | OpenAIRE |
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