The Icsbp locus is a common proviral insertion site in mature B-cell lymphomas/plasmacytomas induced by exogenous murine leukemia virus
| Autor: | David W. Morris, Sandra Kunder, Leticia Quintanilla-Martinez, Karina Dalsgaard Sørensen, Annette Balle Sørensen, Shi Liang Ma, Jörg Schmidt, Finn Skou Pedersen |
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| Rok vydání: | 2006 |
| Předmět: |
Lymphoma
B-Cell Virus Integration B-cell lymphomas Mice Exon Interferon hemic and lymphatic diseases Virology Murine leukemia virus medicine Animals RNA Messenger RNA Neoplasm Insertional mutagenesis Common integration site Base Sequence biology Myeloid leukemia biology.organism_classification medicine.disease Lymphoma Leukemia Virus Murine Haematopoiesis Interferon Regulatory Factors Cancer research IRF8 Plasmacytoma Chronic myelogenous leukemia medicine.drug |
| Zdroj: | Ma, S L, Sørensen, A B, Kunder, S, Sørensen, K D, Quintanilla-Martinez, L, Morris, D W, Schmidt, J & Pedersen, F S 2006, ' The Icsbp locus is a common proviral insertion site in mature B-cell lymphomas/plasmacytomas induced by exogenous murine leukemia virus ', Virology, vol. 352, no. 2, pp. 306-318 . https://doi.org/10.1016/j.virol.2006.05.006 |
| ISSN: | 0042-6822 |
| Popis: | ICSBP (interferon consensus sequence binding protein)/IRF8 (interferon regulatory factor 8) is an interferon gamma-inducible transcription factor expressed predominantly in hematopoietic cells, and down-regulation of this factor has been observed in chronic myelogenous leukemia and acute myeloid leukemia in man. By screening about 1200 murine leukemia virus (MLV)-induced lymphomas, we found proviral insertions at the Icsbp locus in 14 tumors, 13 of which were mature B-cell lymphomas or plasmacytomas. Only one was a T-cell lymphoma, although such tumors constituted about half of the samples screened. This indicates that the Icsbp locus can play a specific role in the development of mature B-lineage malignancies. Two proviral insertions in the last Icsbp exon were found to act by a poly(A)-insertion mechanism. The remaining insertions were found within or outside Icsbp. Since our results showed expression of Icsbp RNA and protein in all end-stage tumor samples, a simple tumor suppressor function of ICSBP is not likely. Interestingly, proviral insertions at Icsbp have not been reported from previous extensive screenings of mature B-cell lymphomas induced by endogenous MLVs. We propose that ICSBP might be involved in an early modulation of an immune response to exogenous MLVs that might also play a role in proliferation of the mature B-cell lymphomas. |
| Databáze: | OpenAIRE |
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