The effect of bromotrifluoromethane on operant behavior in monkeys
| Autor: | Donald N. Farrer, Vernon L. Carter, Kenneth C. Back |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Central Nervous System
Male Pharmacology Time Factors Hydrocarbons Halogenated business.industry Central nervous system Haplorhini Bromine Toxicology chemistry.chemical_compound medicine.anatomical_structure chemistry Anesthesia Avoidance Learning Bromotrifluoromethane Animals Conditioning Operant Medicine Female Operant conditioning business Depression (differential diagnoses) |
| Zdroj: | Toxicology and Applied Pharmacology. 17:648-655 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(70)90039-6 |
| Popis: | Seven monkeys trained on continuous and discrete avoidance performance tasks were exposed to concentrations of bromotrifluoromethane 2 (CBrF 3 ) ranging from 10.5% to 42.0%. Significant performance decrements were observed in all subjects during exposures of 20–25% CBrF 3 . Higher concentrations resulted in impaired performance to the point of complete disruption of operant behavior in some subjects. No visible signs of central nervous system depression or analgesia accompanied this loss of ability to perform on conditioned performance tasks. These results suggest that the mechanism by which CBrF 3 causes impaired performance differs from the central nervous system depression and analgesia produced by halogenated anesthetics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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