A seroprevalence survey of anti-SARS-CoV-2 antibodies among individuals 18 years of age or older living in a vulnerable region of the city of São Paulo, Brazil

Autor: Alexandre Giannecchini Romagnolo, Rafaela Xavier Gomes, Cristóvão Pitangueiras Mangueira, João Luiz Miraglia, Camila Nascimento Monteiro, Ranier Nogueira Dos Santos, Daiana Bonfim, Karina Inacio Ladislau de Carvalho, Eliane Aparecida Rosseto-Welter, Juliana Gabriel Souza, Marina da Gloria Dos Santos
Rok vydání: 2021
Předmět:
Male
RNA viruses
0301 basic medicine
Viral Diseases
Pulmonology
Coronaviruses
Epidemiology
Cross-sectional study
Disease
Antibodies
Viral
Geographical locations
Serology
Medical Conditions
0302 clinical medicine
Seroepidemiologic Studies
Surveys and Questionnaires
Pandemic
Prevalence
030212 general & internal medicine
Asymptomatic Infections
Pathology and laboratory medicine
Virus Testing
education.field_of_study
Disease surveillance
Multidisciplinary
virus diseases
Middle Aged
Medical microbiology
Infectious Diseases
Viruses
Medicine
Female
SARS CoV 2
Pathogens
medicine.symptom
Brazil
Research Article
Adult
SARS coronavirus
Infectious Disease Control
Science
030106 microbiology
Population
Microbiology
Asymptomatic
Respiratory Disorders
03 medical and health sciences
Diagnostic Medicine
medicine
Humans
Seroprevalence
Serologic Tests
Cities
education
Pandemics
Aged
Medicine and health sciences
Biology and life sciences
business.industry
Organisms
Viral pathogens
COVID-19
Covid 19
South America
Microbial pathogens
Cross-Sectional Studies
Respiratory Infections
People and places
business
Demography
Zdroj: PLoS ONE, Vol 16, Iss 7, p e0255412 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: A second wave of COVID-19 has demonstrated how challenging it will be to achieve sustained control of the disease, even with vaccination underway in many countries. Therefore, it remains relevant to keep improving our understanding of the distribution of COVID-19, especially of asymptomatic individuals, among different populations, and particularly in vulnerable regions. Hence, this population-based serosurvey had the objective of estimating the prevalence of individuals 18 years of age or older infected by SARS-CoV-2, and the proportion of asymptomatic individuals, among a vulnerable population living in an urban setting. This was a cross-sectional single-stage cluster sampling serosurvey conducted between September and December of 2019, in a vulnerable region of the city of São Paulo, Brazil. Families covered by three public primary healthcare units represented the selected clusters. After study inclusion, participants were asked about signs and symptoms related to COVID-19, and had collected 10 mL of blood for serology testing. A total of 272 individuals from 185 families were included in the study, out of the 400 eligible individuals for inclusion, resulting in a non-response rate of 32%. The post stratified prevalence of individuals infected by SARS-CoV-2 was 45.2% (95% CI: 39.4–51.0%), with a proportion of asymptomatic cases of 30.2% (95% CI: 23.3–38.0%). This population-based serosurvey identified a greater prevalence of infected individuals by SARS-CoV-2 compared to data from the beginning of the pandemic, and from a recent citywide serosurvey, with a similar proportion of asymptomatic individuals. It demonstrated the value of primary healthcare services for disease surveillance activities, and the importance of more focused serosurveys, especially in vulnerable locations, and the need to evaluate new surveillance strategies to take into account asymptomatic cases.
Databáze: OpenAIRE
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