In vitro anti-trypanosomal effect of ivermectin on Trypanosoma evansi by targeting multiple metabolic pathways

Autor: Snehil Gupta, Sukhdeep Vohra, Khushboo Sethi, Surbhi Gupta, Bidhan Chandra Bera, Sanjay Kumar, Rajender Kumar
Rok vydání: 2022
Předmět:
Zdroj: Tropical Animal Health and Production. 54
ISSN: 1573-7438
0049-4747
DOI: 10.1007/s11250-022-03228-1
Popis: High cytotoxicity and increasing resistance reports of existing chemotherapeutic agents against T. evansi have raised the demand for novel, potent, and high therapeutic index molecules for the treatment of surra in animals. In this regard, repurposing approach of drug discovery has provided an opportunity to explore the therapeutic potential of existing drugs against new organism. With this objective, the macrocyclic lactone representative, ivermectin, has been investigated for the efficacy against T. evansi in the axenic culture medium. To elucidate the potential target of ivermectin in T. evansi, mRNA expression profile of 13 important drug target genes has been studied at 12, 24, and 48 h interval. In the in vitro growth inhibition assay, ivermectin inhibited T. evansi growth and multiplication significantly (p 0.001) with IC
Databáze: OpenAIRE
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