Testicular cancer among US men aged 50 years and older
Autor: | Katherine A. McGlynn, Carsten Rusner, Andreas Stang, Armen A. Ghazarian, Britton Trabert, Megan Braunlin |
---|---|
Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty Epidemiology Medizin Article 03 medical and health sciences 0302 clinical medicine Testicular Neoplasms Risk Factors Spermatocytes Ethnicity medicine Humans Registries Testicular cancer Aged Aged 80 and over Obstetrics business.industry Incidence Incidence (epidemiology) Racial Groups Cancer Histology Seminoma Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease United States Confidence interval 030104 developmental biology Oncology Testicular Lymphoma 030220 oncology & carcinogenesis Germ cell tumors business |
Zdroj: | Cancer Epidemiology. 55:68-72 |
ISSN: | 1877-7821 |
Popis: | Background The incidence of testicular cancer in the United States (US) has substantially increased in recent decades. The majority of testicular cancers are germ cell tumors (TGCT), which are the most commonly occurring malignancies among men aged 15–44 years in the US. To date, few studies have focused on testicular cancer among men aged ≥ 50 years. Thus, we sought to examine detailed descriptive features, including incidence rates and age patterns, of tumors that arise in the testes among men aged ≥ 50 years. Methods Data from forty-one US cancer registries were included for the years 1999–2014. Incidence rates per 100,000 person-years and their 95% confidence intervals (CI) were calculated by race/ethnicity, histology, and age at diagnosis. Estimates of annual percent change (APC) were also calculated. Results Age-specific incidence rates of spermatocytic tumors, sex cord stromal tumors and lymphomas rose with age, while age-specific incidence rates of seminomas and nonseminomas declined. Between 1999 and 2014, the incidence of nonseminoma (APC = 3.26, 95% CI: 2.27–4.25) increased more than any other tumor type. The incidence of seminoma (APC: 1.15, 95% CI: 0.59–1.71) also increased, while rates of testicular lymphoma (APC: −0.66, 95% CI: −1.16 to −0.16), spermatocytic tumors (APC: 0.42, 95% CI: −1.42 to 2.29), and sex cord stromal tumors (APC: 0.60, 95% CI: −3.21 to 4.55) remained relatively unchanged. Conclusion Given the distinct time-trends and age-specific patterns of testicular cancer in men aged ≥50 years, additional investigation of risk factors for these tumors is warranted. |
Databáze: | OpenAIRE |
Externí odkaz: |