Vitreous albumin redox state in open-angle glaucoma patients and controls: a pilot study
| Autor: | Ewald Lindner, Vera H. I. Fengler, Martin Weger, Domagoj Ivastinovic, Anton Haas, Christoph Schwab, Gerald Seidel, Andreas Wedrich, Margret Paar, Karl Oettl |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Open angle glaucoma Glaucoma Pilot Projects medicine.disease_cause Posterior vitreous detachment Redox Ophthalmology Albumins Medicine Humans Intraocular Pressure Aged chemistry.chemical_classification Reactive oxygen species business.industry Albumin medicine.disease eye diseases Vitreous Body Oxidative Stress chemistry Thiol Female sense organs business Reactive Oxygen Species Oxidation-Reduction Oxidative stress Glaucoma Open-Angle |
| Zdroj: | International ophthalmology. 40(4) |
| ISSN: | 1573-2630 |
| Popis: | Purpose Numerous studies suggest that reactive oxygen species play a crucial role in the development of glaucoma. Since glaucoma patients exhibit posterior vitreous detachment earlier than controls, it has been suggested that reactive oxygen species—increased in glaucoma—also affect the vitreous. In the present study we evaluated the influence of open-angle glaucoma oxidative stress on the redox state of vitreous albumin. Methods Albumin redox states of the vitreous and plasma were evaluated in 22 subjects—11 open-angle glaucoma patients and 11 controls—matched for age, gender, and vitreous state. According to the redox state of cysteine-34, albumin can be separated into: human mercaptalbumin (the thiol form), human nonmercaptalbumin1 (a reversible modification due to mild oxidation), and human nonmercaptalbumin2 (an irreversible modification due to severe oxidation). Results Albumin of both, the open-angle glaucoma group and the control group, was more oxidized in the vitreous compared to plasma. Furthermore, significantly higher human nonmercaptalbumin1 fractions were found in the vitreous of open-angle glaucoma patients compared to controls. No significant differences were found in the plasma albumin fractions between the groups. Conclusion Our results support the hypothesis that oxidative stress plays a crucial role in open-angle glaucoma and that reactive oxygen species in glaucomatous eyes may also affect the vitreous. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink