Genome-derived cytosolic DNA contributes to type I interferon expression and immunogenicity of B-cell lymphoma cells
| Autor: | Muznah Khatoo, Samantha S.W. Ho, Florence S.G. Cheung, Nikki Y. Tan, Yu J. Shen, Stephan Gasser, Christine Xing’Er Koo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Lymphoma
B-Cell DNA repair Immunology Biochemistry Endonuclease chemistry.chemical_compound Extrachromosomal DNA Cell Line Tumor medicine Immunology and Allergy Humans Protein–DNA interaction B-cell lymphoma Molecular Biology Genome biology RNA Hematology DNA medicine.disease Molecular biology Proliferating cell nuclear antigen chemistry Interferon Type I biology.protein |
| Zdroj: | Cytokine. 76(2) |
| ISSN: | 1096-0023 |
| Popis: | We recently provided evidence that genome-derived DNA is present in the cytosol of many tumor cells. Genomic loci that give rise to cytosolic DNA can potentially form non-B DNA structures including triple-stranded RNA:DNA structures (R-loops). The RNA:DNA-specific endonuclease RNaseh1 reduced the levels of cytosolic DNA and type I interferon-dependent rejection of B-cell lymphoma suggesting that cytosolic DNA may contribute to immune surveillance of B-cell lymphoma. |
| Databáze: | OpenAIRE |
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