The Effects of Nitric Oxide Supplementation and Inhibition on Bacterial Translocation in Bile Duct Ligated Rats
| Autor: | M. Iyigor, Nil Culhaci, Muharrem Balkaya, Ahmet Ender Demirkiran, Pars Tunçyürek, H. Ozgurn, Mehmet Hakan Çevikel, Neriman Aydin, Şükrü Boylu |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Chromosomal translocation Arginine Nitric Oxide Nitric oxide Rats Sprague-Dawley Random Allocation chemistry.chemical_compound Internal medicine medicine Animals Mesenteric lymph nodes Analysis of Variance biology Bile duct business.industry General Medicine Jaundice Rats Nitric oxide synthase Jaundice Obstructive NG-Nitroarginine Methyl Ester Endocrinology medicine.anatomical_structure Liver chemistry Biliary tract Bacterial Translocation biology.protein Female Surgery medicine.symptom Hepatic fibrosis business |
| Zdroj: | Acta Chirurgica Belgica. 106:202-205 |
| ISSN: | 0001-5458 |
| Popis: | Obstructive jaundice promotes bacterial translocation from the gut, but the role of nitric oxide is controversial in this process. We studied the effects of nitric oxide synthase substrate, L-arginine, and nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, on bacterial translocation in bile duct ligated rats. The animals were randomized into five groups; control, sham, common bile duct ligation alone, nitric oxide inhibition, and nitric oxide supplementation. Obstructive jaundice was performed with common bile duct ligation. L-arginine or N(G)-nitro-L-arginine methyl ester was injected once daily for 14 days. Blood bilirubin level, liver histology, and bacterial translocation to the mesenteric lymph nodes as well as to the liver were assessed. The L-arginine supplemented group had the lowest bacterial translocation rate, but the most prominent hepatic fibrosis. Nitric oxide inhibition increased bacterial translocation to the mesenteric lymph nodes. Therefore, the administration of nitric oxide donor or inhibitor acts as a significant regulatory factor for bacterial translocation in obstructive jaundice. |
| Databáze: | OpenAIRE |
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