Improvement of Rat Survival and Liver Mitochondrial Function in Biliary Obstruction After Treatment With Sodium Thiosulfate
| Autor: | C. Chaimoff, H. Levinsky, S. Kyzer, B. Myslovaty |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Sodium lcsh:Surgery chemistry.chemical_element Sodium thiosulfate Gastroenterology chemistry.chemical_compound Internal medicine medicine lcsh:RC799-869 Survival rate Chemotherapy Hepatology business.industry lcsh:RD1-811 chemistry Surgery Obstructive jaundice lcsh:Diseases of the digestive system. Gastroenterology Liver function business Function (biology) After treatment Research Article |
| Zdroj: | HPB Surgery, Vol 8, Iss 4, Pp 249-252 (1995) HPB Surgery |
| ISSN: | 0894-8569 |
| Popis: | The exact cause of liver failure occurring after long standing biliary obstruction is not known. Impairment of hepatic mitochondrial respiration was postulated in some studies. Sodium thiosulphate (STS) is known to have a protective effect on liver function during administration of hepatotoxic chemotherapy. In the present experimental study the effect of treatment with STS in the presence of obstructive jaundice was studied by determination of the survival rate of rats subjected to biliary obstruction and by polarographic determination of the hepatic mitochondrial function. Treatment with STS was found to result in a significant improvement in rats' survival rate (p < 0.05). Polarography demonstrated significant preservation of mitochondrial respiratory capacity after treatment with STS. The results of the present study show that the deterioration in liver function in the presence of biliary obstruction is probably caused by impairment of mitochondrial respiration. This may be preserved by treatment with STS. The exact explanation of its effect is not yet clear. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text