Infectious diarrhoea in antiretroviral therapy-naive HIV/AIDS patients in Kenya
Autor: | Mkaya Mwamburi, Timothy Kamau, Paul Ngugi, Jane W. Wanyiri, David E. Wang, C. N. Wamae, Gachuhi Kimani, Samuel Maina, Roberta M. O’Connor, Henry M. Kanyi, Tabitha Waithera, Honorine D. Ward |
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Rok vydání: | 2013 |
Předmět: |
Adult
Diarrhea Male medicine.medical_specialty Cross-sectional study Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Feces Immunocompromised Host Acquired immunodeficiency syndrome (AIDS) Risk Factors Water Supply Internal medicine HIV Seropositivity medicine Humans Sanitation biology business.industry digestive oral and skin physiology Public Health Environmental and Occupational Health Dysentery Cryptosporidium Original Articles General Medicine Middle Aged medicine.disease biology.organism_classification Kenya Antiretroviral therapy CD4 Lymphocyte Count Cross-Sectional Studies Infectious Diseases Immunology Etiology Female Parasitology medicine.symptom business |
Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 107:631-638 |
ISSN: | 1878-3503 0035-9203 |
Popis: | Diarrhoea is a significant cause of morbidity and mortality in immunocompromised patients. The objectives of this study were to investigate the aetiological agents, risk factors and clinical features associated with diarrhoea in HIV/AIDS patients in Kenya.Sociodemographic, epidemiological and clinical data were obtained for 164 HIV/AIDS patients (70 with and 94 without diarrhoea) recruited from Kenyatta National Hospital, Kenya. Stool samples were examined for enteric pathogens by microscopy and bacteriology.Intestinal protozoa and fungi were identified in 70% of patients, more frequently in those with diarrhoea (p0.001). Helminths were detected in 25.6% of patients overall, and bacterial pathogens were identified in 51% of patients with diarrhoea. Polyparasitism was more common in patients with diarrhoea than those without (p0.0001). Higher CD4(+) T-cell count (OR = 0.995, 95% CI 0.992-0.998) and water treatment (OR = 0.231, 95% CI 0.126-0.830) were associated with a lower risk of diarrhoea, while close contact with cows (OR = 3.200, 95% CI 1.26-8.13) or pigs (OR = 11.176, 95% CI 3.76-43.56) were associated with a higher risk of diarrhoea.Multiple enteric pathogens that are causative agents of diarrhoea were isolated from stools of antiretroviral therapy-naïve HIV/AIDS patients, indicating a need for surveillance, treatment and promotion of hygienic practices. |
Databáze: | OpenAIRE |
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