Reorganization of the somatosensory cortex in hemiplegic cerebral palsy associated with impaired sensory tracts
| Autor: | Patricia Ellen Grant, Christos Papadelis, Lilla Zöllei, Madelyn Rubenstein, Donna Nimec, Brian D. Snyder, Limin Sun, Erin E. Butler |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Hemiplegic cerebral palsy Adolescent Cognitive Neuroscience Brain reorganization Sensory system Hemiplegia Somatosensory system lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology lcsh:RC346-429 03 medical and health sciences Somatosensory deficits 0302 clinical medicine Discrimination Psychological Neuroimaging Functional neuroimaging Neuroplasticity medicine Gamma Rhythm Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Brain injury Child Cortical plasticity lcsh:Neurology. Diseases of the nervous system Afferent Pathways Brain Mapping Sensory stimulation therapy medicine.diagnostic_test Cerebral Palsy 05 social sciences Magnetoencephalography Regular Article Somatosensory Cortex Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging Neurology Touch Perception lcsh:R858-859.7 Female Neurology (clinical) Psychology Neuroscience Probabilistic diffusion tractography 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 17, Iss, Pp 198-212 (2018) |
| ISSN: | 2213-1582 |
| Popis: | Functional neuroimaging studies argue that sensory deficits in hemiplegic cerebral palsy (HCP) are related to deviant somatosensory processing in the ipsilesional primary somatosensory cortex (S1). A separate body of structural neuroimaging literature argues that these deficits are due to structural damage of the ascending sensory tracts (AST). The relationship between the functional and structural integrity of the somatosensory system and the sensory performance is largely unknown in HCP. To address this relationship, we combined findings from magnetoencephalography (MEG) and probabilistic diffusion tractography (PDT) in 10 children with HCP and 13 typically developing (TD) children. With MEG, we mapped the functionally active regions in the contralateral S1 during tactile stimulation of the thumb, middle, and little fingers of both hands. Using these MEG-defined functional active regions as regions of interest for PDT, we estimated the diffusion parameters of the AST. Somatosensory function was assessed via two-point discrimination tests. Our MEG data showed: (i) an abnormal somatotopic organization in all children with HCP in either one or both of their hemispheres; (ii) longer Euclidean distances between the digit maps in the S1 of children with HCP compared to TD children; (iii) suppressed gamma responses at early latencies for both hemispheres of children with HCP; and (iv) a positive correlation between the Euclidean distances and the sensory tests for the more affected hemisphere of children with HCP. Our MEG-guided PDT data showed: (i) higher mean and radian diffusivity of the AST in children with HCP; (ii) a positive correlation between the axial diffusivity of the AST with the sensory tests for the more affected hemisphere; and (iii) a negative correlation between the gamma power change and the AD of the AST for the MA hemisphere. Our findings associate for the first time bilateral cortical functional reorganization in the S1 of HCP children with abnormalities in the structural integrity of the AST, and correlate these abnormalities with behaviorally-assessed sensory deficits. Graphical abstract Image 1 Highlights • Hemiplegic CP exhibits abnormal somatotopy in one or both hemispheres. • Hemiplegic CP shows longer distances between digit somatosensory representations. • Suppressed gamma somatosensory responses are seen in hemiplegic CP. • Altered somatosensory organization is associated with deficient sensory fibers. • Injury of sensory fibers correlates with the severity of sensory deficits. |
| Databáze: | OpenAIRE |
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