Seasonal variation of respiratory pathogen colonization in asymptomatic health care professionals: A single-center, cross-sectional, 2-season observational study
| Autor: | Elena Grigorenko, David Weisman, Esmeralda Asis, Stanley Lu, Scott Clemmons, Khushdeep Chahal, Leslie Malone, Jessica Green, Don Stalons, Ali Hassoun, Matthew Huff |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Staphylococcus aureus Epidemiology Health Personnel education Viral colonization Infection control medicine.disease_cause Asymptomatic Article Virus Microbiology Moraxella catarrhalis Young Adult Klebsiella Nasopharynx Nosocomial infections medicine Humans Colonization Respiratory Tract Infections Pathogen transmission Coronavirus Cross Infection biology business.industry Health Policy Public Health Environmental and Occupational Health Bacterial Infections Middle Aged Bacterial colonization biology.organism_classification medicine.disease Hospitals Cross-Sectional Studies Infectious Diseases Virus Diseases Carrier State Alabama Female Seasons Klebsiella pneumonia medicine.symptom business |
| Zdroj: | American Journal of Infection Control |
| ISSN: | 0196-6553 |
| DOI: | 10.1016/j.ajic.2015.04.195 |
| Popis: | Background The purpose of this study was to determine the seasonal variance of potentially pathogenic bacterial and viral organisms in nasopharyngeal specimens obtained from asymptomatic health care professionals (HCPs) during the 2014 winter and summer months. Methods Nasopharyngeal specimens from 100 HCPs were collected from Huntsville Hospital (Huntsville, AL) during the winter and from 100 HCPs during the summer. All subjects were tested for 22 viruses and 19 bacteria using Target Enriched Multiplex Polymerase Chain Reaction. Both seasonal cohorts were composed of students, nurses, physicians, and residents. Results Of the 100 HCPs tested during the winter, 34 subjects were colonized with at least 1 bacterium, and 11 tested positive for at least 1 virus. Methicillin-resistant Staphylococcus aureus (MRSA), Moraxella catarrhalis, and coronavirus were the most frequently detected potentially infectious agents. Of the 100 HCPs tested during the summer, 37 tested positive for at least 1 bacterium, and 4 tested positive for a viral agent. The most prevalent bacteria were MRSA and Klebsiella pneumonia. Conclusion Nasopharyngeal carriage among asymptomatic HCPs was common, but the frequency and presence of potential pathogens varied with each season. Understanding the colonization and infection potential of upper respiratory organisms is important, particularly for viruses. Although asymptomatic HCPs certainly harbor a number of different potentially infectious agents, future studies are needed to determine whether colonized pathogens are transmitted or initiate infection in at-risk patient populations. Graphical abstract Highlights • Respiratory pathogen species and prevalence varied in summer and winter. • Three different viruses were detected in asymptomatic health care professionals in each season. • Multiplex polymerase chain reaction assists in uncovering colonization patterns in bacteria and viruses. • Links between colonization in health care professionals and infection in at-risk patients may exist. |
| Databáze: | OpenAIRE |
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