| Autor: |
Andrés M. Álvarez-Constantino, Andrea Álvarez-Pérez, Jesús A. Varela, Giuseppe Sciortino, Gregori Ujaque, Carlos Saá |
| Přispěvatelé: |
Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares, Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Popis: |
The Ru-catalyzed intramolecular oxidative amidation (lactamization) of aromatic alkynylamines with 4-picoline N-oxide as an external oxidant has been developed. This chemoselective process is very efficient to achieve medium-sized ε- and ζ-lactams (seven- and eight-membered rings) but not for the formation of common δ-lactams (six-membered rings). DFT studies unveiled the capital role of the chain length between the amine and the alkyne functionalities: the longer the connector, the more favored the lactamization process vs hydroamination. This work has received financial support from MICINN (projects PID2020-118048GB-I00, PID2020-116861GB-I00, and ORFEO-CINQA network RED2018-102387-T), the Xunta de Galicia (project ED431C 2022/27, Centro singular de investigación de Galicia accreditation 2019-2022, ED431G 2019/03), and the European Union (European Regional Development Fund) SI |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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