CHEMERIN IS AN INDEPENDENT MARKER OF THE METABOLIC SYNDROME IN A CAUCASIAN POPULATION - A PILOT STUDY
| Autor: | Marek Svestak, David Stejskal, Zuzana Hanulova, Milan Karpisek |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Waist medicine.medical_treatment Adipokine Sensitivity and Specificity White People General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Humans Chemerin Aged Metabolic Syndrome biology business.industry Insulin Middle Aged medicine.disease Endocrinology Blood pressure chemistry biology.protein Intercellular Signaling Peptides and Proteins Uric acid Female Chemokines Metabolic syndrome business Body mass index Biomarkers |
| Zdroj: | Biomedical Papers. 152:217-221 |
| ISSN: | 1804-7521 1213-8118 |
| DOI: | 10.5507/bp.2008.033 |
| Popis: | AIM: Chemerin is a novel adipokine that has been suggested to play an important role in the pathogenesis of the metabolic syndrome. The aim of our study was to evaluate serum chemerin as a marker of the metabolic syndrome and to assess its predictive accuracy in a Caucasian population. METHODS: The study was designed as a cross-sectional study. Anthropometric measurements and serum analyses were done for Body Mass Index, waist circumference, chemerin, insulin, triacylglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, and glucose in 55 non-obese healthy subjects and 181 subjects at risk for the metabolic syndrome. ROC curves were determined and the Chi-squared test was used to analyse the data. RESULTS: Compared with healthy controls, subjects with suspected metabolic syndrome had significantly higher chemerin serum levels (medians: 266.0 vs.192.5 µg/l; P < 0.01). After further chemerin adjustment, the difference between the subgroups persisted. Chemerin serum levels correlated with age (r = 0.23), serum glucose (r = 0.23), HDL-cholesterol (r = -0.19), triacylglycerides (r = 0.22), systolic and diastolic blood pressure (r = 0.40; r = 0.24) and the number of metabolic syndrome risk factors (r = 0.47). At a serum chemerin cut-off level of 240 µg/l, the presence of the metabolic syndrome was diagnosed with 75 % sensitivity and 67 % specificity. CONCLUSION: In conclusion, serum chemerin levels are associated with the characteristics of the metabolic syndrome and could be an independent marker of this disorder in a Caucasian population. |
| Databáze: | OpenAIRE |
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