Birthweight and the Prevalence, Progression, and Incidence of CKD in a Multideterminant Model in a High-Risk Australian Aboriginal Community
| Autor: | Cheryl E. Swanson, Susan A. Mott, Wendy E. Hoy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
education.field_of_study estimated glomerular filtration rate business.industry Incidence (epidemiology) Population Renal function Glomerulonephritis Context (language use) medicine.disease albuminuria kidney disease incidence and progression birthweight Clinical Research Nephrology Internal medicine medicine Albuminuria medicine.symptom Young adult education business Australian Aboriginal Kidney disease |
| Zdroj: | Kidney International Reports |
| ISSN: | 2468-0249 |
| DOI: | 10.1016/j.ekir.2021.08.010 |
| Popis: | Introduction We have previously showed that albuminuria was associated with low birthweight in young adults in a remote Australian Aboriginal community that has high rates of kidney disease. Here we describe the association of birthweight with incidence and progression of kidney disease over time. Methods Among 695 members of an Aboriginal community with recorded birthweights, urine albumin creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured at ages 5 to 40 years, and follow-up values were measured or imputed again a median of 11.6 years later. Prevalence of markers on each occasion and change over time were evaluated in the context of birthweights and other potentially significant factors. Results On the second screen, ACR was inversely and significantly correlated with birthweight and eGFR was directly correlated with birthweight. Increases in ACR and in proportions of persons who developed new-onset (incident) albuminuria between screens were higher in those of lower birthweights ( Graphical abstract |
| Databáze: | OpenAIRE |
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