Coordination difficulties, IQ and psychopathology in children with high-risk copy number variants

Autor: Michael John Owen, Jeremy Hall, Adam C. Cunningham, Marianne Bernadette van den Bree
Rok vydání: 2019
Předmět:
Male
coordination
Autism Spectrum Disorder
Intelligence
Psychological intervention
Anxiety
Neurodevelopmental disorder
0302 clinical medicine
Medicine
Child
Applied Psychology
Motor skill
Intelligence Tests
0303 health sciences
Intelligence quotient
motor skills
05 social sciences
Motor coordination
Psychiatry and Mental health
Autism spectrum disorder
Trait
Female
medicine.symptom
050104 developmental & child psychology
Psychopathology
Clinical psychology
Adolescent
DNA Copy Number Variations
CNV
autism
03 medical and health sciences
ADHD
Humans
Attention deficit hyperactivity disorder
0501 psychology and cognitive sciences
Genetic Predisposition to Disease
development
030304 developmental biology
business.industry
Siblings
Original Articles
medicine.disease
Mental health
IQ
Attention Deficit Disorder with Hyperactivity
Neurodevelopmental Disorders
Autism
business
030217 neurology & neurosurgery
copy number variants
Zdroj: Psychological Medicine
ISSN: 1469-8978
0033-2917
Popis: BackgroundThe prevalence and impact of motor coordination difficulties in children with copy number variants associated with neurodevelopmental disorders (ND-CNVs) remains unknown. This study aims to advance understanding of motor coordination difficulties in children with ND-CNVs and establish relationships between intelligence quotient (IQ) and psychopathology.Methods169 children with an ND-CNV (67% male, median age = 8.88 years, range 6.02–14.81) and 72 closest-in-age unaffected siblings (controls; 55% male, median age = 10.41 years, s.d. = 3.04, range 5.89–14.75) were assessed with the Developmental Coordination Disorder Questionnaire, alongside psychiatric interviews and standardised assessments of IQ.ResultsThe children with ND-CNVs had poorer coordination ability (b = 28.98, p < 0.001) and 91% of children with an ND-CNV screened positive for suspected developmental coordination disorder, compared to 19% of controls (OR = 42.53, p < 0.001). There was no difference in coordination ability between ND-CNV genotypes (F = 1.47, p = 0.184). Poorer coordination in children with ND-CNV was associated with more attention deficit hyperactivity disorder (ADHD) (β = −0.18, p = 0.021) and autism spectrum disorder trait (β = −0.46, p < 0.001) symptoms, along with lower full-scale (ß = 0.21, p = 0.011), performance (β = −0.20, p = 0.015) and verbal IQ (β = 0.17, p = 0.036). Mediation analysis indicated that coordination ability was a full mediator of anxiety symptoms (69% mediated, p = 0.012), and a partial mediator of ADHD (51%, p = 0.001) and autism spectrum disorder trait symptoms (66%, p < 0.001) as well as full scale IQ (40%, p = 0.002), performance IQ (40%, p = 0.005) and verbal IQ (38%, p = 0.006) scores.ConclusionsThe findings indicate that poor motor coordination is highly prevalent and closely linked to risk of mental health disorder and lower intellectual function in children with ND-CNVs. Future research should explore whether early interventions for poor coordination ability could ameliorate neurodevelopmental risk.
Databáze: OpenAIRE
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