Experimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6ТNF
| Autor: | Alexey A. Kubanov, O. A. Obraztsova, A. A. Nikonorov, A E Karamova, V G Semenova, D A Verbenko, V S Solomka, Dmitry Deryabin, Kh M Vanchugova |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
DNA Bacterial Longevity Mice Nude Adaptive Immunity General Biochemistry Genetics and Molecular Biology Host Specificity BALB/c 03 medical and health sciences Mice 0302 clinical medicine Leprosy medicine Animals Humans Mycobacterium leprae Mice Knockout Mice Inbred BALB C biology Strain (chemistry) Tumor Necrosis Factor-alpha Proliferation activity General Medicine medicine.disease biology.organism_classification Molecular biology Immunity Innate Mice Inbred C57BL Disease Models Animal 030104 developmental biology Mice Inbred CBA Russian federation 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 169(6) |
| ISSN: | 1573-8221 |
| Popis: | Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF-/- mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF-/- mice. |
| Databáze: | OpenAIRE |
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