Synthesis and microbiological activity of some N-(2-hydroxy-4-substitutedphenyl)benzamides, phenylacetamides and furamides as the possible metabolites of antimicrobial active benzoxazoles
| Autor: | Esin Aki-Sener, Kamuran K. Bingöl, Nurten Altanlar, Ismail Yalcin, Ozlem Temiz-Arpaci |
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| Rok vydání: | 2002 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared Stereochemistry Nitro compound Pharmaceutical Science Microbial Sensitivity Tests Gram-Positive Bacteria Chemical synthesis Anti-Infective Agents Acetamides Candida albicans Gram-Negative Bacteria Drug Discovery Organic chemistry Furans Antibacterial agent chemistry.chemical_classification Benzoxazoles Dose-Response Relationship Drug biology Antimicrobial biology.organism_classification Anti-Bacterial Agents chemistry Benzamides Antibacterial activity Bacteria Pseudomonadaceae |
| Zdroj: | Il Farmaco. 57:451-456 |
| ISSN: | 0014-827X |
| DOI: | 10.1016/s0014-827x(02)01226-0 |
| Popis: | The synthesis of some N-(2-hydroxy-4-substitutedphenyl)benzamides, phenylacetamides and furamides as the possible metabolites of benzoxazoles (II1-15) was performed in order to determine their in vitro antimicrobial activity against three Gram-positive bacteria, two Gram-negative bacteria and the fungus Candida albicans and their activities were compared with several control drugs. The compounds II11, II12, and II13 were found active at a MIC value of 12.5 microg/ml against the Gram-negative microorganism Pseudomonas aeruginosa. Most of the compounds show antibacterial activity at MIC a value of 25 microg/ml against the Gram-positive bacteria Staphylococcus aureus. For the antifungal activity against C. albicans, compound II10 was found more active than the other derivatives. The antimicrobial activity of some of these benzamides, phenylacetamides (II1 and II10) which are the possible metabolites of benzoxazoles, was also compared to their corresponding cyclic analogues III-IV. Compound II10 possesses two dilutions better antifungal activity than its cyclic analogue, benzoxazole IV, against C. albicans. |
| Databáze: | OpenAIRE |
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