Association between toenail scandium levels and risk of acute myocardial infarction in European men: the EURAMIC and Heavy Metals Study

Autor: A. Aro, J. Gomez-Aracena, P. van 't Veer, Mario Gutiérrez-Bedmar, L. Gorgojo, P. Bode, R.A. Riemersma, H. Wedel, Jeremy D. Kark, Antonio García-Rodríguez, F.J. Kok, Jose M. Martin-Moreno, Enrique Gómez-Gracia, J. Fernandez-Crehuet, A.F.M. Kardinaal
Rok vydání: 2002
Předmět:
Male
0301 basic medicine
tissue level
correlation analysis
Health
Toxicology and Mutagenesis
scandium
Myocardial Infarction
010501 environmental sciences
alpha tocopherol
Toxicology
01 natural sciences
Gastroenterology
chemistry.chemical_compound
Lycopene
Risk Factors
metal recovery
Scandium
Myocardial infarction
Family history
selenium
Rare earth elements
beta carotene
family history
adult
article
risk assessment
Middle Aged
adipose tissue
Heavy metals
Health
diabetes mellitus
Biological Markers
Antioxidant
Risk assessment
cardiovascular risk
medicine.medical_specialty
mercury
hypertension
toe
alcohol consumption
chemistry.chemical_element
Physiological Sciences
smoking
heart protection
coronary risk
03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
Humans
controlled study
human
0105 earth and related environmental sciences
030102 biochemistry & molecular biology
business.industry
Public Health
Environmental and Occupational Health
Case-control study
heavy metal
case control study
medicine.disease
major clinical study
body mass
body burden
Surgery
acute heart infarction
oleic acid
Nails
chemistry
Case-Control Studies
alpha-Tocopherol
business
Biomarkers
Zdroj: Scopus-Elsevier
Toxicology and Industrial Health, 7, 18, 353-360
ISSN: 1477-0393
0748-2337
DOI: 10.1191/0748233702th156oa
Popis: The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 micro/kg in cases and 7.75 microg/kg in controls. Scandium among controls, adjusted for age and centre was positively associated with concentrations of lycopene and oleic acid in adipose tissue (P = 0.002 for both nutrients). Pearson correlations adjusted for age and centre were significant (P0.05) between scandium and lycopene (r = 0.08), zinc (r = 0.08), mercury (r = 0.18) and oleic acid (r = 0.21). Overall, cases had lower levels of scandium than controls after adjustment for age and centre (case control ratio, 0.87; 95% CI 0.79-0.96). This association persisted after adjustment for other cardiovascular risk factors (case-control ratio 0.88; 95% CI, 0.79-0.98). The risk of MI at high scandium levels was reduced after adjustment for age and centre (P-trend = 0.04). Further adjustments for BMI, history of hypertension, smoking, alcohol intake, diabetes, family history of CHD, alpha-tocopherol, beta-carotene, lycopene, selenium and mercury slightly attenuated this trend (P = 0.055). Our results suggest that toenail scandium level is associated with a reduced risk of acute MI, but we are uncertain whether this element can really play a protective role in the development of CHD. Without an identified plausible mechanism, these results should be regarded as preliminary and should be tested in future studies.
Databáze: OpenAIRE
Externí odkaz: