Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

Autor: Isabelle Colle, Mieke Dewerchin, Jean Olivier Contreres, Jean-Marie Rakic, Evelyne Dupuy, Philippe Bonnin, Christophe Van Steenkiste, Sonja Loges, Hans Van Vlierberghe, Bart Jonckx, Vincent Lambert, Agnès Noël, Thomas Schmidt, Imke Albrecht, Wei Hong Xiao, Geert Carmeliet, Lieve Coenegrachts, Anja Geerts, Michael Detmar, Tibor Schomber, Sara Van de Veire, Tine Van Bergen, Stefan Vinckier, Mauro Giacca, Gerhard Christofori, Carole Le Henaff, Ingeborg Stalmans, Peter Carmeliet, Sonia Tugues, Charlotte Rolny, Henar Cuervo, Annemilaï Tijeras-Raballand, Hajimu Oura, Daniela Dettori, Manuel Morales-Ruiz, Gérard Tobelem, Massimiliano Mazzone, Lena Claesson-Welsh, Ian Buysschaert, Patrick H. Maxwell, Desire Collen, Wladimiro Jiménez, Maria De Mol, Stanley A. Vinores, Femke Heindryckx, Jean-Michel Foidart, Jurgen Haustraete, José Vilar, Behzad Kharabi Masouleh, Patricia Hainaud, Serena Zacchigna
Přispěvatelé: S. V., De, I., Stalman, F., Heindryckx, H., Oura, A., Tijeras Raballand, T., Schmidt, S., Loge, I., Albrecht, B., Jonckx, S., Vinckier, C. V., Steenkiste, S., Tugue, C., Rolny, M. D., Mol, D., Dettori, P., Hainaud, L., Coenegracht, J., Contrere, T. V., Bergen, H., Cuervo, W., Xiao, C. L., Henaff, I., Buysschaert, B. K., Masouleh, A., Geert, T., Schomber, P., Bonnin, V., Lambert, J., Haustraete, Zacchigna, Serena, J., Rakic, W., Jiménez, A., Noël, Giacca, Mauro, I., Colle, J., Foidart, G., Tobelem, M., Morales Ruiz, J., Vilar, P., Maxwell, S. A., Vinore, G., Carmeliet, M., Dewerchin, L., Claesson Welsh, E., Dupuy, H. V., Vlierberghe, G., Christofori, M., Mazzone, M., Detmar, D., Collen, P., Carmeliet
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Angiogenesis Inhibitors
therapeutic use
Animals
Antibodies

Monoclonal
therapeutic use
Carcinoma

Hepatocellular
blood supply/prevention /&/ control
Choroid

blood supply
Disease Models

Animal
Eye Diseases

pathology
Humans
Liver Neoplasms

Experimental
blood supply/prevention /&/ control
Mice
Mice

Inbred BALB C
Mice

Inbred C57BL
Mice

Transgenic
Neovascularization

Physiologic
drug effects
Papilloma

blood supply/chemically induced/prevention /&/ control
Pregnancy Proteins

antagonists /&/ inhibitors/metabolism
Skin Neoplasms

blood supply/chemically induced/prevention /&/ control
Skin Neoplasms
Eye Diseases
Angiogenesis
blood supply
Disease Model

Pregnancy Proteins
Inbred C57BL
Transgenic
Metastasis
antagonists /&/ inhibitors/metabolism
Neovascularization
Mice
Liver Neoplasms
Experimental

0302 clinical medicine
Inbred BALB C
Mice
Inbred BALB C

0303 health sciences
Cellcylce
Liver Neoplasms
Antibodies
Monoclonal

blood supply
therapeutic use
Animals
Antibodie

3. Good health
Animal
Eye Disease

030220 oncology & carcinogenesis
pathology
Humans
Liver Neoplasm

medicine.symptom
Cellimunno
Angiogenesis Inhibitor
Carcinoma
Hepatocellular

Transgene
Neovascularization
Physiologic

Mice
Transgenic

Biology
General Biochemistry
Genetics and Molecular Biology

Antibodies
Humdisease
03 medical and health sciences
medicine
Animals
Choroid
Disease Models
Animal

Humans
Mice
Inbred C57BL

Papilloma
Placenta Growth Factor
Gene silencing
030304 developmental biology
Phenocopy
blood supply/chemically induced/prevention /&/ control
Pregnancy Protein

Biochemistry
Genetics and Molecular Biology(all)

Animal
Carcinoma
Cancer
medicine.disease
antagonists /&/ inhibitors/metabolism
Skin Neoplasm

therapeutic use
blood supply/prevention /&/ control
drug effects
Immunology
Disease Models
Cancer research
pathology
Zdroj: Cell
Popis: SummaryOur findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.
Databáze: OpenAIRE