Localization of an abundant myeloid-related sequence
| Autor: | W.M. Mars, J.W. White, Grady F. Saunders, C. M. Stellrecht |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Myeloid
Biology chemistry.chemical_compound hemic and lymphatic diseases medicine Leukocytes Humans RNA Messenger RNA Neoplasm neoplasms Sequence (medicine) Messenger RNA Cdna cloning Base Sequence cDNA library Hematology General Medicine DNA medicine.disease Hematopoietic Stem Cells Molecular biology medicine.anatomical_structure chemistry Leukemia Myeloid Poly A Promyelocyte Chronic myelogenous leukemia Chromosomes Human Pair 8 |
| Zdroj: | Acta haematologica. 78 |
| ISSN: | 0001-5792 |
| Popis: | Differential screening of a CML-derived cDNA library was used to isolate a cDNA clone representing an abundant mRNA in leukocytes of chronic phase, chronic myelogenous leukemia (CML) patients. This myeloid-related sequence (mrs) comprises approximately 2% of the chronic phase, CML mRNA. Hybridization of the radiolabeled cDNA to the cellular RNAs of intact, morphologically distinguishable, primary hematopoietic cells indicates that the primary cells producing mrs RNA are eosinophils (Eo), basophils (Baso), promyelocytes (Pro) and myelocytes (Mye). In the neutrophilic series, the abundance of mrs RNA decreases as the cells mature. The mrs RNA potentially encodes a 93 amino acid protein that has not been previously described. It has been localized to chromosome 8, region 8q21.1-23. |
| Databáze: | OpenAIRE |
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