Simultaneous evaluation of antioxidative serum profiles facilitates the diagnostic screening of autism spectrum disorder in under-6-year-old children
| Autor: | Yumiko Nagano, Daisuke Kurita, Shigeru Oowada, Hiromu Ito, Keiko Iwata, Aki Hirayama, Kenji Tsuchiya, Keisuke Wakusawa, Yosuke Kameno, Toru Fujioka, Tomoyasu Wakuda, Noriyoshi Usui, Hideo Matsuzaki, Masatsugu Tsujii, Takaharu Hirai, Shu Takagai, Takahiro Nara |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Autism Spectrum Disorder Ubiquinone lcsh:Medicine medicine.disease_cause behavioral disciplines and activities Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine mental disorders medicine Humans Diagnostic screening Child lcsh:Science Coenzyme Q10 Multidisciplinary Superoxide business.industry lcsh:R Diagnostic markers Odds ratio Autism spectrum disorders medicine.disease Serum samples Oxidative Stress 030104 developmental biology Endocrinology chemistry Autism spectrum disorder Case-Control Studies Child Preschool Female lcsh:Q Reactive Oxygen Species business Biomarkers 030217 neurology & neurosurgery Oxidative stress Oxidation rate |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | This case–control study aimed to assess oxidative stress alterations in autism spectrum disorder (ASD). We used the MULTIS method, an electron spin resonance-based technique measuring multiple free radical scavenging activities simultaneously, in combination with conventional oxidative stress markers to investigate the ability of this MULTIS approach as a non-behavioural diagnostic tool for children with ASD. Serum samples of 39 children with ASD and 58 age-matched children with typical development were analysed. The ASD group showed decreased hydroxyl radical (·OH) and singlet oxygen scavenging activity with increased serum coenzyme Q10 oxidation rate, indicating a prooxidative tendency in ASD. By contrast, scavenging activities against superoxide (O2·−) and alkoxyl radical (RO·) were increased in the ASD group suggesting antioxidative shifts. In the subgroup analysis of 6-year-olds or younger, the combination of ·OH, O2·−, and RO· scavenging activities predicted ASD with high odds ratio (50.4), positive likelihood (12.6), and percentage of correct classification (87.0%). Our results indicate that oxidative stress in children with ASD is not simply elevated but rather shows a compensatory shift. MULTIS measurements may serve as a very powerful non-behavioural tool for the diagnosis of ASD in children. |
| Databáze: | OpenAIRE |
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