Hepatitis C virus (HCV) incidence among men who have sex with men (MSM) living with HIV: results from the French Hospital Database on HIV (ANRS CO4-FHDH) cohort study, 2014 to 2017

Autor: Jonathan Bellet, Gilles Pialoux, Anthony Cousien, Dominique Costagliola, Mathieu Castry, Karen Champenois, Yazdan Yazdanpanah, Sophie Grabar, Sylvie Deuffic-Burban
Přispěvatelé: Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service des maladies infectieuses et tropicales [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de santé publique [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Deuffic-Burban, Sylvie, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], French Hospital Database on HIV (ANRS CO4-FHDH Cohort), Service de Maladies infectieuses et tropicales [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), HAL-SU, Gestionnaire
Rok vydání: 2021
Předmět:
Male
medicine.medical_specialty
Epidemiology
Hepatitis C virus
HIV Infections
Hepacivirus
medicine.disease_cause
Antiviral Agents
Men who have sex with men
Serology
Cohort Studies
Sexual and Gender Minorities
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Virology
Internal medicine
cohort study
medicine
Humans
MSM
030212 general & internal medicine
Homosexuality
Male
DAA
ANRS CO4-FHDH
Transmission (medicine)
business.industry
Incidence
Research
Incidence (epidemiology)
Public Health
Environmental and Occupational Health
HIV
virus diseases
Hepatitis C
Chronic
Treatment as prevention
Hepatitis C
Hospitals
3. Good health
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Cohort
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
030211 gastroenterology & hepatology
business
HCV incidence rate
Cohort study
Zdroj: Eurosurveillance
Eurosurveillance, European Centre for Disease Prevention and Control, 2021, 26 (38), pp.2001321. ⟨10.2807/1560-7917.es.2021.26.38.2001321⟩
Eurosurveillance, 2021, 26 (38), ⟨10.2807/1560-7917.ES.2021.26.38.2001321⟩
Eurosurveillance, 2021, 26 (38), pp.2001321. ⟨10.2807/1560-7917.es.2021.26.38.2001321⟩
ISSN: 1560-7917
1025-496X
Popis: Background Despite the availability of highly effective direct-acting antivirals (DAAs) and the expected treatment as prevention (TasP) effect, transmission of hepatitis C virus (HCV) persists in men who have sex with men (MSM) who engage in high-risk sexual behaviours. Aim We aimed to estimate the incidence of primary HCV infection among MSM living with HIV in France when DAA was readily available. Methods We used data from a large French hospital cohort of persons living with HIV (ANRS CO4-FHDH) prospectively collected between 2014 and 2017. HCV incidence rates were calculated using person-time methods for HCV-negative MSM at inclusion who had serological follow-up from 1 January 2014 to 31 December 2017. Sensitivity analyses were performed by varying the main assumptions to assess their impact on the results. Results Of 14,273 MSM living with HIV who were initially HCV-seronegative, 330 acquired HCV during follow-up over 45,866 person-years (py), resulting in an overall estimated incidence rate of 0.72/100 py (95% CI: 0.65–0.80). HCV incidence significantly decreased from 0.98/100 py (95% CI: 0.81–1.19) in 2014 to 0.45/100 py (95% CI: 0.35–0.59) in 2017 (54% decrease; 95% CI: 36–67). This trend was confirmed by most of the sensitivity analyses. Conclusion The primary incidence of HCV was halved for MSM living with HIV between 2014 and 2017. This decrease may be related to unrestricted DAA availability in France for individuals living with HIV. Further interventions, including risk reduction, are needed to reach HCV micro-elimination in MSM living with HIV.
Databáze: OpenAIRE
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