Bioaccessibility, Intestinal Permeability and Plasma Stability of Isorhamnetin Glycosides from Opuntia ficus-indica (L.)
| Autor: | Janet A. Gutiérrez-Uribe, Marilena Antunes-Ricardo, Eduardo Cepeda-Cañedo, Sergio O. Serna-Saldívar, César Rodríguez-Rodríguez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Opuntia ficus-indica Glycosylation Flavonoid Biological Availability bioaccessibility permeability glycosides isorhamnetin flavonoids Catalysis Article Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Intestinal mucosa In vivo Animals Humans Physical and Theoretical Chemistry Intestinal Mucosa Molecular Biology lcsh:QH301-705.5 Spectroscopy Isorhamnetin Chromatography High Pressure Liquid chemistry.chemical_classification 030109 nutrition & dietetics Chromatography Molecular Structure Plant Extracts Organic Chemistry Glycoside Opuntia Reproducibility of Results 04 agricultural and veterinary sciences General Medicine 040401 food science Computer Science Applications Rats Aglycone chemistry lcsh:Biology (General) lcsh:QD1-999 Quercetin |
| Zdroj: | International Journal of Molecular Sciences, Vol 18, Iss 8, p 1816 (2017) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 18; Issue 8; Pages: 1816 |
| ISSN: | 1422-0067 |
| Popis: | Isorhamnetin glycosides are representative compounds of Opuntia ficus-indica that possess different biological activities. There is slight information about the changes in bioaccessibility induced by the glycosylation pattern of flavonoids, particularly for isorhamnetin. In this study, the bioaccessibility and permeability of isorhamnetin glycosides extracted from O. ficus-indica were contrasted with an isorhamnetin standard. Also, the plasma stability of these isorhamnetin glycosides after intravenous administration in rats was evaluated. Recoveries of isorhamnetin after oral and gastric digestion were lower than that observed for its glycosides. After intestinal digestion, isorhamnetin glycosides recoveries were reduced to less than 81.0%. The apparent permeability coefficient from apical (AP) to basolateral (BL) direction (Papp(AP-BL)) of isorhamnetin was 2.6 to 4.6-fold higher than those obtained for its glycosides. Isorhamnetin diglycosides showed higher Papp(AP-BL) values than triglycosides. Sugar substituents affected the Papp(AP-BL) of the triglycosides. Isorhamnetin glycosides were better retained in the circulatory system than the aglycone. After intravenous dose of the isorhamnetin standard, the elimination half-life was 0.64 h but increased to 1.08 h when the O. ficus-indica extract was administered. These results suggest that isorhamnetin glycosides naturally found in O. ficus-indica could be a controlled delivery system to maintain a constant plasmatic concentration of this important flavonoid to exert its biological effects in vivo. |
| Databáze: | OpenAIRE |
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