The importance of including ethnically diverse populations in studies of quantitative trait evolution
| Autor: | Alexander Platt, Sarah A. Tishkoff, Chao Zhang, Michael A. McQuillan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
media_common.quotation_subject
Quantitative Trait Loci Large population Quantitative variation Quantitative trait locus Biology Article 03 medical and health sciences 0302 clinical medicine Ethnicity Genetics Humans Selection Genetic Categorical variable 030304 developmental biology media_common 0303 health sciences Genetic Variation Ethnically diverse Biological Evolution Genetics Population Phenotype Variation (linguistics) Evolutionary biology Adaptation human activities 030217 neurology & neurosurgery Developmental Biology Diversity (politics) |
| Zdroj: | Curr Opin Genet Dev |
| ISSN: | 0959-437X |
| DOI: | 10.1016/j.gde.2020.05.037 |
| Popis: | For many traits, human variation is less a matter of categorical differences than quantitative variation, such as height, where individuals fall along a continuum from short to tall. Most recent studies utilize large population-based samples with whole-genome sequences to study the evolution of these traits and have made significant progress implementing a broad spectrum of techniques. However, relatively few studies of quantitative trait evolution include ethnically diverse populations, which often harbor the highest levels of genetic and phenotypic diversity. Thus, our ability to draw inferences about quantitative trait adaptation has been limited. Here, we review recent studies examining human quantitative trait adaptation, and argue that including ethnically diverse populations, particularly from Africa, will be especially informative for our understanding of how humans adapt to the world around them. |
| Databáze: | OpenAIRE |
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